Literature DB >> 17975259

Transforming growth factor-beta receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?

Nima Sharifi1, Robert J Lechleider, William L Farrar.   

Abstract

The transforming growth factor-beta (TGF-beta) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-beta receptor III is the most common TGF-beta pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.

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Year:  2007        PMID： 17975259     DOI： 10.1677/JME-07-0084

Source DB:  PubMed          Journal:  J Mol Endocrinol        ISSN： 0952-5041            Impact factor:   5.098


  6 in total

1.  Vasectomy: potential links to an increased risk of aggressive prostate cancer?

Authors:  Alexis R Gaines; Adriana C Vidal; Stephen J Freedland
Journal:  Expert Rev Anticancer Ther       Date:  2015-09-07       Impact factor: 4.512

2.  microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis.

Authors:  Aaron E Hoffman; Tongzhang Zheng; Chunhui Yi; Derek Leaderer; Joanne Weidhaas; Frank Slack; Yawei Zhang; Trupti Paranjape; Yong Zhu
Journal:  Cancer Res       Date:  2009-06-30       Impact factor: 12.701

3.  The reciprocal interactions between astrocytes and prostate cancer cells represent an early event associated with brain metastasis.

Authors:  Eliane Gouvêa de Oliveira Barros; Antonio Palumbo; Pedro Lucas Prado Mello; Rômulo Medina de Mattos; Julianna Henriques da Silva; Bruno Pontes; Nathan Bessa Viana; Rackele Ferreira do Amaral; Flavia Regina Souza Lima; Nathalia Meireles da Costa; Celia Yelimar Palmero; Leandro Miranda-Alves; Christina Maeda Takiya; Luiz Eurico Nasciutti
Journal:  Clin Exp Metastasis       Date:  2014-02-01       Impact factor: 5.150

Review 4.  More than an accessory: implications of type III transforming growth factor-beta receptor loss in prostate cancer.

Authors:  Seun Ajiboye; Tristan M Sissung; Nima Sharifi; William D Figg
Journal:  BJU Int       Date:  2010-01-08       Impact factor: 5.588

5.  Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow.

Authors:  Kenji Yumoto; Matthew R Eber; Jingcheng Wang; Frank C Cackowski; Ann M Decker; Eunsohl Lee; Ana Rita Nobre; Julio A Aguirre-Ghiso; Younghun Jung; Russell S Taichman
Journal:  Sci Rep       Date:  2016-11-07       Impact factor: 4.379

6.  Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer.

Authors:  P Balanathan; E D Williams; H Wang; J S Pedersen; L G Horvath; M G Achen; S A Stacker; G P Risbridger
Journal:  Br J Cancer       Date:  2009-05-12       Impact factor: 7.640
  6 in total

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