Literature DB >> 1797523

Is drug use a response to stress?

F O'Doherty1.   

Abstract

The perceived impact of life events on drug use was tested and specifically the hypothesis that drug use is a response to stress. Three groups of drug users were examined: heroin users, heavy drinkers and smokers. These were compared to non-drug using controls and the frequency of life events in the lives of each group was recorded. Whereas both the heroin and alcohol groups reported more stressful life events in their lives, no such difference was found for the smokers when compared to their control group. However, the differences between the heroin users and their control group on the one hand, and between the drinkers and their control group on the other, were found to consist largely of events which were consequences of the drug use itself. Furthermore, these two drug user groups (alcohol and heroin respectively) apparently experienced less stressful events than their control groups when events unconnected with drug use were examined alone. Nonetheless, this is interpreted as due to the way these groups perceive events rather than as an accurate record of their experiences. The conclusion is that heroin and alcohol use act as stress 'buffers', in that they reduce awareness of ongoing stressful life events. But in so doing they introduce a lot of new stresses which possibly maintain the drug use and therefore ultimately increase stress.

Entities:  

Mesh:

Year:  1991        PMID: 1797523     DOI: 10.1016/0376-8716(91)90026-u

Source DB:  PubMed          Journal:  Drug Alcohol Depend        ISSN: 0376-8716            Impact factor:   4.492


  6 in total

Review 1.  Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress.

Authors:  Anthony A Grace
Journal:  Neurotox Res       Date:  2010-02-09       Impact factor: 3.911

2.  Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats.

Authors:  Y Shaham; J Stewart
Journal:  Psychopharmacology (Berl)       Date:  1994-04       Impact factor: 4.530

3.  Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.

Authors:  Y Shaham
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

4.  Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens.

Authors:  C Garcia-Keller; S A Martinez; M A Esparza; F Bollati; P W Kalivas; L M Cancela
Journal:  Eur J Neurosci       Date:  2013-01-29       Impact factor: 3.386

5.  Stressful Life Events and Relapse Among Formerly Alcohol Dependent Adults.

Authors:  Daniel J Pilowsky; Katherine M Keyes; Timothy J Geier; Bridget F Grant; Deborah S Hasin
Journal:  Soc Work Ment Health       Date:  2013

6.  Substance Use Attenuates Physiological Responses Associated With PTSD among Individuals with Co-Morbid PTSD and SUDs.

Authors:  Telsie A Davis; Tanja Jovanovic; Seth Davin Norrholm; Ebony M Glover; Mahogany Swanson; Sarah Spann; Bekh Bradley
Journal:  J Psychol Psychother       Date:  2013-08-30
  6 in total

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