BACKGROUND: Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history. PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004. Survival and prognostic factors for survival were analyzed. RESULTS: Median age was 52 years. Primary sites were the breast (35%), skin (20%) and soft tissues (13%). At initial diagnosis, 31 (19%) had metastases. Surgery was the first treatment in 121 (75%) patients combined with chemotherapy or radiotherapy in 34 and 32, respectively. Ninety (74%) of these 121 patients relapsed, mostly locally (50). With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died. Median survival was 3.4 years [95% confidence interval (CI) 2.4-5.8], and the 5-year overall survival (OS) rate was 43% (95% CI 33-53). In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS. PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival. CONCLUSIONS: Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.
BACKGROUND:Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history. PATIENTS AND METHODS: We reviewed 161 files of angiosarcoma treated in three institutions of the French Sarcoma Group from 1980 to 2004. Survival and prognostic factors for survival were analyzed. RESULTS: Median age was 52 years. Primary sites were the breast (35%), skin (20%) and soft tissues (13%). At initial diagnosis, 31 (19%) had metastases. Surgery was the first treatment in 121 (75%) patients combined with chemotherapy or radiotherapy in 34 and 32, respectively. Ninety (74%) of these 121 patients relapsed, mostly locally (50). With an average time since initial diagnosis of 8.1 years, 123 (76%) patients progressed and 76 (47%) died. Median survival was 3.4 years [95% confidence interval (CI) 2.4-5.8], and the 5-year overall survival (OS) rate was 43% (95% CI 33-53). In multivariate analysis, liver primary site [relative risk (RR) = 12.62], performance status (PS) of two or more (RR = 3.83), presence of metastases at diagnosis (RR = 2.50), soft tissue tumor (RR = 0.31) were correlated to OS. PS, liver and soft tissue tumors were identified as independent prognostic factors for progression-free survival. CONCLUSIONS:Angiosarcomas have an overall poor outcome, but with a clearly distinct prognosis depending on the primary site.
Authors: Michael Kranzfelder; Margit Bauer; Thomas Richter; Martina Rudelius; Martin Huth; Peter Wagner; Helmut Friess; Josef Stadler Journal: J Gastrointest Surg Date: 2011-11-09 Impact factor: 3.452
Authors: Antoine Italiano; Chun-Liang Chen; Rachael Thomas; Matthew Breen; Françoise Bonnet; Nicolas Sevenet; Michel Longy; Robert G Maki; Jean-Michel Coindre; Cristina R Antonescu Journal: Cancer Date: 2012-05-30 Impact factor: 6.860
Authors: Sandra P D'Angelo; Rodrigo R Munhoz; Deborah Kuk; Johnathan Landa; Eliza W Hartley; Michael Bonafede; Mark A Dickson; Mrinal Gounder; Mary L Keohan; Aimee M Crago; Cristina R Antonescu; William D Tap Journal: Oncology Date: 2015-06-03 Impact factor: 2.935
Authors: Richard J Cassidy; Jeffrey M Switchenko; Melinda L Yushak; Nicholas Madden; Mohammad K Khan; David K Monson; Jonathan J Beitler; Jerome C Landry; Karen D Godette; Theresa W Gillespie; Kirtesh R Patel Journal: Surg Oncol Date: 2018-09-13 Impact factor: 3.279
Authors: Johanna Manner; Bernhard Radlwimmer; Peter Hohenberger; Katharina Mössinger; Stefan Küffer; Christian Sauer; Djeda Belharazem; Andreas Zettl; Jean-Michel Coindre; Christian Hallermann; Jörg Thomas Hartmann; Detlef Katenkamp; Kathrin Katenkamp; Patrick Schöffski; Raf Sciot; Agnieszka Wozniak; Peter Lichter; Alexander Marx; Philipp Ströbel Journal: Am J Pathol Date: 2009-12-11 Impact factor: 4.307
Authors: Martina Zemanova; Katarina Machalekova; Monika Sandorova; Elena Boljesikova; Marta Skultetyova; Juraj Svec; Andrej Zeman Journal: Rep Pract Oncol Radiother Date: 2013-08-23
Authors: Darya Buehler; Stephanie R Rice; John S Moody; Patrick Rush; Gholam-Reza Hafez; Steven Attia; B Jack Longley; Kevin R Kozak Journal: Am J Clin Oncol Date: 2014-10 Impact factor: 2.339