Literature DB >> 17973874

Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans.

J J Kelly1, S H Tam, P M Williamson, J A Whitworth.   

Abstract

1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

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Year:  2007        PMID： 17973874     DOI： 10.1111/j.1440-1681.2007.04700.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  3 in total

1.  The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects.

Authors:  P M Williamson; S L H Ong; J A Whitworth; J J Kelly
Journal:  J Hum Hypertens       Date:  2015-03-26       Impact factor: 3.012

2.  Twice daily fractionated dose administration of prednisolone compared to standard once daily administration to patients with glomerulonephritis or with kidney transplants.

Authors:  Sebastian Oliver Decker; Frieder Keller; Jens Mayer; Sylvia Stracke
Journal:  Med Klin (Munich)       Date:  2009-06-16

3.  Influence of aerobic exercise training on cardiovascular and endocrine-inflammatory biomarkers in hypertensive postmenopausal women.

Authors:  Aline P Jarrete; Iane P Novais; Hygor A Nunes; Guilherme M Puga; Maria A Delbin; Angelina Zanesco
Journal:  J Clin Transl Endocrinol       Date:  2014-07-11
  3 in total

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