[5HT-3 receptors: characteristics and therapeutic implications of a new subtype of 5-hydroxytryptamine receptors].

5HT-3 receptors, as well as their selective agonists and antagonists have been recently discovered. They are localized exclusively on the nervous elements of the peripheral and central nervous system, and are involved in the regulation of emesis, in pain, motility and secretion of the gut, and possibly in some functions of the central nervous system. At present, the 5HT-3 antagonists are used in the therapy of emesis induced by cytostatic drugs, radiation and in some intestinal disorders. Further experimental and clinical studies are needed to evaluate the use of 5HT-3 antagonists in the therapy of pain (migraine), some cognitive, and affective disorders and addiction.