BACKGROUND: Carcinomas of the salivary glands are uncommon heterogeneous tumors characterized by locoregional invasion and distant metastasis. Angiogenesis is a necessary condition for invasion and metastasis, and vascular endothelial growth factor (VEGF) is considered a prime mediator of this process. The relationship between VEGF and clinical outcome in cancers of diverse locations has been examined, yielding inconclusive results. PATIENTS AND METHODS: An immunohistochemical study was conducted on the expression of VEGF protein in 66 salivary gland carcinomas and the relation between VEGF and clinicopathological parameters explored. RESULTS: VEGF expression was seen in 41 tumors (62%) and was correlated with lymph node metastasis (p<0.005), clinical stage (p<0.02), cause-specific survival (p<0.01) and local failure-free survival (p<0.02). CONCLUSION: VEGF can contribute to the progression of salivary gland carcinomas and seems to be associated with neck node metastasis, worse survival and poor local control of the disease.
BACKGROUND:Carcinomas of the salivary glands are uncommon heterogeneous tumors characterized by locoregional invasion and distant metastasis. Angiogenesis is a necessary condition for invasion and metastasis, and vascular endothelial growth factor (VEGF) is considered a prime mediator of this process. The relationship between VEGF and clinical outcome in cancers of diverse locations has been examined, yielding inconclusive results. PATIENTS AND METHODS: An immunohistochemical study was conducted on the expression of VEGF protein in 66 salivary gland carcinomas and the relation between VEGF and clinicopathological parameters explored. RESULTS:VEGF expression was seen in 41 tumors (62%) and was correlated with lymph node metastasis (p<0.005), clinical stage (p<0.02), cause-specific survival (p<0.01) and local failure-free survival (p<0.02). CONCLUSION:VEGF can contribute to the progression of salivary gland carcinomas and seems to be associated with neck node metastasis, worse survival and poor local control of the disease.
Authors: Pawel Sowa; Karolina Goroszkiewicz; Joanna Szydelko; Joanna Chechlinska; Katarzyna Pluta; Wojciech Domka; Maciej Misiolek; Wojciech Scierski Journal: Biomed Res Int Date: 2018-08-01 Impact factor: 3.411
Authors: Fabricio L D Vieira; Beatriz J Vieira; Marco A M Guimaraes; Fernando M Aarestrup Journal: BMC Oral Health Date: 2008-09-02 Impact factor: 2.757