Literature DB >> 1797233

Tg (9 HSA-MYC), a homozygous lethal insertion in the mouse.

S Tutois1, J Salaun, M G Mattei, J L Guénet.   

Abstract

Transgenic mice generated with different DNA sequences were surveyed for possible homozygous mutant phenotypes. We found an embryonic lethal mutation in the transgenic mouse strain (MT-MYC12.4) containing the human c-myc gene. Embryos homozygous for the transgene die shortly after implantation. The strain MT-MYC12.4 carries approximately 50 tandem copies of the recombinant plasmid sequence. The 3' flanking sequence has been cloned and analyzed. It contains a unique sequence that has been conserved during evolution and maps to Chromosome (Chr) 9. This mutant has been designated Tg 9 (HSA-MYC).

Entities:  

Mesh：

Year:  1991        PMID： 1797233     DOI： 10.1007/BF00351065

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  34 in total

1.  Molecular genetic analysis of the dilute-short ear (d-se) region of the mouse.

Authors:  E M Rinchik; L B Russell; N G Copeland; N A Jenkins
Journal:  Genetics       Date:  1986-02       Impact factor: 4.562

Review 2.  Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse.

Authors:  S Gluecksohn-Waelsch
Journal:  Cell       Date:  1979-02       Impact factor: 41.582

3.  Early developmental mutations due to DNA rearrangements in transgenic mouse embryos.

Authors:  L Covarrubias; Y Nishida; B Mintz
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1985

4.  Isolation and characterization of the mouse metallothionein-I gene.

Authors:  D M Durnam; F Perrin; F Gannon; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

5.  Association of the lethal yellow (Ay) coat color mutation with an ecotropic murine leukemia virus genome.

Authors:  N G Copeland; N A Jenkins; B K Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

6.  Insertional mutation in a transgenic mouse allelic with Purkinje cell degeneration.

Authors:  T F Krulewski; P E Neumann; J W Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

7.  Analysis of the integrant in MyK-103 transgenic mice in which males fail to transmit the integrant.

Authors:  T M Wilkie; R D Palmiter
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272

8.  Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant.

Authors:  X Xiang; K F Benson; K Chada
Journal:  Science       Date:  1990-02-23       Impact factor: 47.728

9.  Legless, a novel mutation found in PHT1-1 transgenic mice.

Authors:  J D McNeish; W J Scott; S S Potter
Journal:  Science       Date:  1988-08-12       Impact factor: 47.728

10.  Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

Authors:  N A Jenkins; N G Copeland; B A Taylor; B K Lee
Journal:  Nature       Date:  1981-10-01       Impact factor: 49.962
View more
  3 in total

Review 1.  Mouse chromosome 9.

Authors:  D M Kingsley
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  The same genomic region is disrupted in two transgene-induced limb deformity alleles.

Authors:  T F Vogt; L Jackson-Grusby; A J Wynshaw-Boris; D C Chan; P Leder
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 3.  Insertional mutagenesis in transgenic mice.

Authors:  T Rijkers; A Peetz; U Rüther
Journal:  Transgenic Res       Date:  1994-07       Impact factor: 2.788
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.