BACKGROUND: Salivary ductal carcinoma (SDC) is an uncommon malignant tumor of the salivary glands. Although there is no known standard of care for the treatment of advanced disease, the vast majority of patients with SDC may be offered palliative systemic therapy. We report a case of epidermal growth factor receptor 2 (HER2)-positive metastatic submandibular SDC with a complete and durable clinical response to treatment with trastuzumab in combination with chemotherapy. METHODS AND RESULTS: A 62-year-old man was diagnosed with SDC of the left submandibular gland with extensive cervical lymph node involvement. The lesion was completely resected, and the patient underwent postoperative radiotherapy. After 6 months, multiple pulmonary metastatic lesions were detected. A complete response was reached with trastuzumab-based combination therapy, and no evidence of disease progression has been observed after 14 months of initiation of systemic therapy. CONCLUSION: Trastuzumab-based combination therapies should be considered for advanced SDC.
BACKGROUND:Salivary ductal carcinoma (SDC) is an uncommon malignant tumor of the salivary glands. Although there is no known standard of care for the treatment of advanced disease, the vast majority of patients with SDC may be offered palliative systemic therapy. We report a case of epidermal growth factor receptor 2 (HER2)-positive metastatic submandibular SDC with a complete and durable clinical response to treatment with trastuzumab in combination with chemotherapy. METHODS AND RESULTS: A 62-year-old man was diagnosed with SDC of the left submandibular gland with extensive cervical lymph node involvement. The lesion was completely resected, and the patient underwent postoperative radiotherapy. After 6 months, multiple pulmonary metastatic lesions were detected. A complete response was reached with trastuzumab-based combination therapy, and no evidence of disease progression has been observed after 14 months of initiation of systemic therapy. CONCLUSION:Trastuzumab-based combination therapies should be considered for advanced SDC.
Authors: Elina Salovaara; Olli Hakala; Leif Bäck; Petri Koivunen; Kauko Saarilahti; Fabricio Passador-Santos; Ilmo Leivo; Antti A Mäkitie Journal: Eur Arch Otorhinolaryngol Date: 2012-03-22 Impact factor: 2.503
Authors: Ann-Jean C C Beck; Peter J F M Lohuis; Abrahim Al-Mamgani; Laura A Smit; Willem M C Klop Journal: Eur Arch Otorhinolaryngol Date: 2018-05-21 Impact factor: 2.503
Authors: Sewanti A Limaye; Marshall R Posner; Jeffrey F Krane; Maria Fonfria; Jochen H Lorch; Deborah A Dillon; Aditya V Shreenivas; Roy B Tishler; Robert I Haddad Journal: Oncologist Date: 2013-02-21
Authors: Tiziana Negri; Elena Tamborini; Gian Paolo Dagrada; Angela Greco; Samantha Staurengo; Marco Guzzo; Laura D Locati; Antonino Carbone; Marco A Pierotti; Lisa Licitra; Silvana Pilotti Journal: Transl Oncol Date: 2008-09 Impact factor: 4.243