Literature DB >> 17971996

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

Jeffery J Newsome1, Marie A Colucci, Mary Hassani, Howard D Beall, Christopher J Moody.   

Abstract

A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.

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Year:  2007        PMID： 17971996     DOI： 10.1039/b713044a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

Authors:  Jeffery J Newsome; Mary Hassani; Elizabeth Swann; Jane M Bibby; Howard D Beall; Christopher J Moody
Journal:  Bioorg Med Chem       Date:  2013-04-06       Impact factor: 3.641

2.  Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells.

Authors:  Hong Yu; Hong-Ying Gao; Hua Guo; Gui-Zhen Wang; Yi-Qing Yang; Qian Hu; Li-Jun Liang; Qun Zhao; Da-Wei Xie; Yu Rao; Guang-Biao Zhou
Journal:  Acta Pharmacol Sin       Date:  2021-05-25       Impact factor: 6.150

3.  The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.

Authors:  Clare F Megarity; James R E Gill; M Clare Caraher; Ian J Stratford; Karen A Nolan; David J Timson
Journal:  FEBS Lett       Date:  2014-03-12       Impact factor: 4.124

Review 4.  NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places.

Authors:  Angel L Pey; Clare F Megarity; David J Timson
Journal:  Biosci Rep       Date:  2019-01-03       Impact factor: 3.840

5.  Synthesis of N-Fused Benzimidazole-4,7-diones via Sequential Copper-Catalyzed C-N Coupling/Cyclization and Oxidation.

Authors:  Pham Duy Quang Dao; Son Long Ho; Chan Sik Cho
Journal:  ACS Omega       Date:  2018-05-25

6.  Synthesis of Pyrimidine- and Quinazoline-Fused Benzimidazole-4,7-diones Using Combinatorial Cyclocondensation and Oxidation.

Authors:  Dong Young Kim; Pham Duy Quang Dao; Chan Sik Cho
Journal:  ACS Omega       Date:  2018-12-17
  6 in total

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