Literature DB >> 17971737

Efficient Ce(NO3)3 x 6H2O-catalyzed solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones.

Mehdi Adib1, Khadijeh Ghanbary, Manizheh Mostofi, Mohammad Reza Ganjali.   

Abstract

Cerium(III) nitrate hexahydrate efficiently catalyzes the three-component Biginelli reaction under solvent-free conditions of an aldehyde, a beta-keto ester or beta-diketone and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or -thiones in excellent yields.

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Year:  2006        PMID： 17971737      PMCID： PMC6148571          DOI： 10.3390/11080649

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  11 in total

1.  Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.

Authors:  S J Haggarty; T U Mayer; D T Miyamoto; R Fathi; R W King; T J Mitchison; S L Schreiber
Journal:  Chem Biol       Date:  2000-04

2.  Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.

Authors:  T U Mayer; T M Kapoor; S J Haggarty; R W King; S L Schreiber; T J Mitchison
Journal:  Science       Date:  1999-10-29       Impact factor: 47.728

3.  Green chemistry approaches to the synthesis of 5-alkoxycarbonyl-4-aryl-3,4- dihydropyrimidin-2(1H)-ones by a three-component coupling of one-pot condensation reaction: comparison of ethanol, water, and solvent-free conditions.

Authors:  D Subhas Bose; Liyakat Fatima; Hari Babu Mereyala
Journal:  J Org Chem       Date:  2003-01-24       Impact factor: 4.354

4.  Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Authors:  G C Rovnyak; S D Kimball; B Beyer; G Cucinotta; J D DiMarco; J Gougoutas; A Hedberg; M Malley; J P McCarthy; R Zhang
Journal:  J Med Chem       Date:  1995-01-06       Impact factor: 7.446

5.  In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Authors:  J C Barrow; P G Nantermet; H G Selnick; K L Glass; K E Rittle; K F Gilbert; T G Steele; C F Homnick; R M Freidinger; R W Ransom; P Kling; D Reiss; T P Broten; T W Schorn; R S Chang; S S O'Malley; T V Olah; J D Ellis; A Barrish; K Kassahun; P Leppert; D Nagarathnam; C Forray
Journal:  J Med Chem       Date:  2000-07-13       Impact factor: 7.446

6.  A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate(1).

Authors:  C. Oliver Kappe
Journal:  J Org Chem       Date:  1997-10-17       Impact factor: 4.354

7.  Fluorous Synthesis: Fluorous Protocols for the Ugi and Biginelli Multicomponent Condensations.

Authors:  Armido Studer; Patrick Jeger; Peter Wipf; Dennis P. Curran
Journal:  J Org Chem       Date:  1997-05-02       Impact factor: 4.354

8.  Lanthanide triflate catalyzed Biginelli reaction. one-pot synthesis of dihydropyrimidinones under solvent-free conditions.

Authors:  Y Ma; C Qian; L Wang; M Yang
Journal:  J Org Chem       Date:  2000-06-16       Impact factor: 4.354

9.  Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Authors:  G C Rovnyak; K S Atwal; A Hedberg; S D Kimball; S Moreland; J Z Gougoutas; B C O'Reilly; J Schwartz; M F Malley
Journal:  J Med Chem       Date:  1992-08-21       Impact factor: 7.446

10.  Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.

Authors:  K S Atwal; B N Swanson; S E Unger; D M Floyd; S Moreland; A Hedberg; B C O'Reilly
Journal:  J Med Chem       Date:  1991-02       Impact factor: 7.446
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  3 in total

1.  Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.

Authors:  Ozkan Sari; Vincent Roy; Mathieu Métifiot; Christophe Marchand; Yves Pommier; Stéphane Bourg; Pascal Bonnet; Raymond F Schinazi; Luigi A Agrofoglio
Journal:  Eur J Med Chem       Date:  2015-09-25       Impact factor: 6.514

2.  Ultrasound-assisted synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-(1H)-(thio)ones catalyzed by Sm(ClO(4))(3).

Authors:  Chen-Jiang Liu; Ji-De Wang
Journal:  Molecules       Date:  2010-03-24       Impact factor: 4.411

3.  Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones.

Authors:  Chen-Jiang Liu; Ji-De Wang
Journal:  Molecules       Date:  2009-02-13       Impact factor: 4.411
  3 in total

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