BACKGROUND: The addition of bevacizumab to 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) improved the time-to-progression (TTP) and overall survival (OS) in comparison to FOLFOX in the second-line treatment of metastatic colorectal cancer (MCRC). However, limited survival data are available to support FOLFOX plus bevacizumab in a first-line setting. We conducted a retrospective study of first-line FOLFOX plus bevacizumab to better characterize the safety and efficacy of this regimen in the first-line treatment of MCRC. METHODS: Records of patients treated with first-line FOLFOX plus bevacizumab between January 2003 and March 2006 were reviewed. Grade 3 and 4 toxicity as well as efficacy data were collected. TTP and OS analyses were done using the Kaplan-Meier method. RESULTS: 51 patients were treated with FOLFOX plus bevacizumab. Oxaliplatin treatment was interrupted prior to progression in 67% of patients. Grade 3 neuropathy, neutropenia and diarrhea occurred in 16, 8, and 8% of patients, respectively. The overall response rate, median TTP and median OS were 41%, 9.9 months and 23.2 months, respectively. CONCLUSIONS: First-line FOLFOX plus bevacizumab is associated with favorable TTP and OS. The definitive role of bevacizumab in the first-line setting in combination with FOLFOX chemotherapy should be explored further in randomized clinical trials. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: The addition of bevacizumab to 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) improved the time-to-progression (TTP) and overall survival (OS) in comparison to FOLFOX in the second-line treatment of metastatic colorectal cancer (MCRC). However, limited survival data are available to support FOLFOX plus bevacizumab in a first-line setting. We conducted a retrospective study of first-line FOLFOX plus bevacizumab to better characterize the safety and efficacy of this regimen in the first-line treatment of MCRC. METHODS: Records of patients treated with first-line FOLFOX plus bevacizumab between January 2003 and March 2006 were reviewed. Grade 3 and 4 toxicity as well as efficacy data were collected. TTP and OS analyses were done using the Kaplan-Meier method. RESULTS: 51 patients were treated with FOLFOX plus bevacizumab. Oxaliplatin treatment was interrupted prior to progression in 67% of patients. Grade 3 neuropathy, neutropenia and diarrhea occurred in 16, 8, and 8% of patients, respectively. The overall response rate, median TTP and median OS were 41%, 9.9 months and 23.2 months, respectively. CONCLUSIONS: First-line FOLFOX plus bevacizumab is associated with favorable TTP and OS. The definitive role of bevacizumab in the first-line setting in combination with FOLFOX chemotherapy should be explored further in randomized clinical trials. Copyright 2007 S. Karger AG, Basel.
Authors: Herbert I Hurwitz; Benjamin R Tan; James A Reeves; Henry Xiong; Brad Somer; Heinz-Josef Lenz; Howard S Hochster; Frank Scappaticci; John F Palma; Richard Price; John J Lee; Alan Nicholas; Nicolas Sommer; Johanna Bendell Journal: Oncologist Date: 2018-12-14
Authors: Lee Chun Park; Ho Sup Lee; Seong Hoon Shin; Seun Ja Park; Moo In Park; Sung Yong Oh; Hyuk Chan Kwon; Jin Ho Baek; Young Jin Choi; Myoung Joo Kang; Yang Soo Kim Journal: World J Gastroenterol Date: 2012-03-14 Impact factor: 5.742
Authors: Yong Sang Hong; Hyeon Jin Cho; Sun Young Kim; Kyung Hae Jung; Ji Won Park; Hyo Seong Choi; Jae Hwan Oh; Byung Chang Kim; Dae Kyung Sohn; Dae Yong Kim; Hee Jin Chang Journal: BMC Cancer Date: 2009-07-21 Impact factor: 4.430