Literature DB >> 17971032

Graded function of CD80 and CD86 in initiation of T-cell immune response and cardiac allograft survival.

Jianbin Xiang1, Xiaodong Gu, Shiguang Qian, Zongyou Chen.   

Abstract

CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4), which have opposing functions in T-cell responses, share the two ligands, CD80 (B7-1) and CD86 (B7-2). To understand the functions of CD80 and CD86, respectively, CD80(low) dendritic cells (DCs) and CD86(low) DCs were prepared by using RNA interference. Then CD80 and CD86 functions were analysed by in vitro mixed lymphocyte reaction and cytokine production assay. Effect on cardiac allograft survival was assayed in vivo. In this study, graded stimulatory function of CD80 and CD86, stronger inhibition of proliferation, and stronger prolongation of transplant survival were observed when CD80 and CD86 were blocked simultaneously.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17971032     DOI： 10.1111/j.1432-2277.2007.00590.x

Source DB:  PubMed          Journal:  Transpl Int        ISSN： 0934-0874            Impact factor:   3.782


  8 in total

1.  The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.

Authors:  Jian Wu; Lu Xia; Xiangyu Yao; Xiao Yu; Keyla C Tumas; Wenxiang Sun; Yang Cheng; Xiao He; Yu-Chih Peng; Brajesh K Singh; Cui Zhang; Chen-Feng Qi; Silvia Bolland; Sonja M Best; Channe Gowda; Ruili Huang; Timothy G Myers; Carole A Long; Rong-Fu Wang; Xin-Zhuan Su
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-30       Impact factor: 11.205

Review 2.  RNA interference for improving the outcome of islet transplantation.

Authors:  Feng Li; Ram I Mahato
Journal:  Adv Drug Deliv Rev       Date:  2010-12-13       Impact factor: 15.470

3.  B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.

Authors:  Melanie A Ruffner; Seon Hee Kim; Nicole R Bianco; Loise M Francisco; Arlene H Sharpe; Paul D Robbins
Journal:  Eur J Immunol       Date:  2009-11       Impact factor: 5.532

4.  Circulating cytokine portraits can differentiate between allograft rejection and pulmonary infection in cardiac transplant rats.

Authors:  Hao Chen; Feng Li; Yanxia Zhan; Weiyong Yu; Chen Lu; Yunfeng Cheng; Yunqing Mei
Journal:  Interact Cardiovasc Thorac Surg       Date:  2016-03-22

5.  The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma.

Authors:  Wenxiu Zhao; Weixue Su; Penghao Kuang; Lei Zhang; Jianming Liu; Zhenyu Yin; Xiaomin Wang
Journal:  Int J Oncol       Date:  2012-05-24       Impact factor: 5.650

6.  Robust Phenotypic Activation of Eosinophils during Experimental Toxocara canis Infection.

Authors:  Joice Margareth de Almeida Rodolpho; Luciana Camillo; Márcio Sobreira Silva Araújo; Elaine Speziali; Jordana Grazziela Coelho-Dos-Reis; Ricardo de Oliveira Correia; Débora Meira Neris; Olindo Assis Martins-Filho; Andréa Teixeira-Carvalho; Fernanda de Freitas Anibal
Journal:  Front Immunol       Date:  2018-01-31       Impact factor: 7.561

7.  NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.

Authors:  Andrew S Marriott; Olga Vasieva; Yongxiang Fang; Nikki A Copeland; Alexander G McLennan; Nigel J Jones
Journal:  PLoS One       Date:  2016-05-04       Impact factor: 3.240

8.  The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis.

Authors:  Tuerhongjiang Tuxun; Shadike Apaer; Hai-Zhang Ma; Heng Zhang; Amina Aierken; Ren-Yong Lin; Hao Wen
Journal:  J Immunol Res       Date:  2015-10-05       Impact factor: 4.818
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.