Literature DB >> 17968817

Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.

Elizabeth A Lowenhaupt1, Kelly Matson, Bushra Qureishi, Akihiko Saitoh, David Pugatch.   

Abstract

Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

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Year:  2007        PMID： 17968817     DOI： 10.1086/522764

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  7 in total

1.  Absence seizures associated with efavirenz initiation.

Authors:  Renate Strehlau; Leigh Martens; Ashraf Coovadia; Collet Dandara; Jennifer Norman; Julia Maisel; Louise Kuhn; Elaine J Abrams
Journal:  Pediatr Infect Dis J       Date:  2011-11       Impact factor: 2.129

2.  Can therapeutic drug monitoring improve pharmacotherapy of HIV infection in adolescents?

Authors:  Natella Y Rakhmanina; John N van den Anker; Steven J Soldin; Ron H van Schaik; Nick Mordwinkin; Michael N Neely
Journal:  Ther Drug Monit       Date:  2010-06       Impact factor: 3.681

3.  Association between efavirenz as initial therapy for HIV-1 infection and increased risk for suicidal ideation or attempted or completed suicide: an analysis of trial data.

Authors:  Katie R Mollan; Marlene Smurzynski; Joseph J Eron; Eric S Daar; Thomas B Campbell; Paul E Sax; Roy M Gulick; Lumine Na; Lauren O'Keefe; Kevin R Robertson; Camlin Tierney
Journal:  Ann Intern Med       Date:  2014-07-01       Impact factor: 25.391

4.  Neuropsychiatric sequelae in an efavirenz treated patient with hepatitis B.

Authors:  Emma Salter; Anish S Patel
Journal:  BMJ Case Rep       Date:  2009-11-26

Review 5.  Antiretroviral medication: an emerging category of prescription drug misuse.

Authors:  Glen P Davis; Hilary L Surratt; Frances R Levin; Carlos Blanco
Journal:  Am J Addict       Date:  2013-09-17

6.  Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation.

Authors:  Francoise Pinillos; Collet Dandara; Marelize Swart; Renate Strehlau; Louise Kuhn; Faeezah Patel; Ashraf Coovadia; Elaine Abrams
Journal:  BMC Infect Dis       Date:  2016-02-02       Impact factor: 3.090

7.  Factors associated with loss-to-follow-up of HIV-positive mothers and their infants enrolled in HIV care clinic: A qualitative study.

Authors:  S Mpinganjira; T Tchereni; A Gunda; V Mwapasa
Journal:  BMC Public Health       Date:  2020-03-06       Impact factor: 3.295
  7 in total

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