| Literature DB >> 17967421 |
Masayuki Kaneko1, Saori Yasui, Yoshifumi Niinuma, Kiho Arai, Tomohiro Omura, Yasunobu Okuma, Yasuyuki Nomura.
Abstract
Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.Entities:
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Year: 2007 PMID： 17967421 DOI： 10.1016/j.febslet.2007.10.033
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124