Literature DB >> 17966115

Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future.

Geoffrey Férir1, Suzanne Kaptein, Johan Neyts, Erik De Clercq.   

Abstract

A decade ago, standard therapy against chronic hepatitis B virus infections only consisted of lamivudine or IFN-alpha. Treatment with lamivudine and IFN has been compounded by, respectively, the emergence of drug-resistant virus strains and the appearance of serious side effects. In the last 10 years, hepatitis B treatment has made much progress. Several treatments are now licensed for the treatment of patients with chronic hepatitis B and others are under development. Here, we provide an overview of the potential and mode of action of anti-HBV agents that are currently available, and/or may become available in the near future. Foremost among these newer compounds are adefovir dipivoxil, entecavir and telbivudine. John Wiley & Sons, Ltd

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Year:  2008        PMID： 17966115     DOI： 10.1002/rmv.554

Source DB:  PubMed          Journal:  Rev Med Virol        ISSN： 1052-9276            Impact factor:   6.989


  18 in total

1.  High persistence rate of hepatitis B virus in a hydrodynamic injection-based transfection model in C3H/HeN mice.

Authors:  Xiu-Hua Peng; Xiao-Nan Ren; Li-Xiang Chen; Bi-Sheng Shi; Chun-Hua Xu; Zhong Fang; Xue Liu; Jie-Liang Chen; Xiao-Nan Zhang; Yun-Wen Hu; Xiao-Hui Zhou
Journal:  World J Gastroenterol       Date:  2015-03-28       Impact factor: 5.742

2.  Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.

Authors:  Guangyan Liu; Xiancai Ma; Zhe Wang; Kousho Wakae; Yaochang Yuan; Zhangping He; Hironori Yoshiyama; Hisashi Iizasa; Hui Zhang; Mami Matsuda; Ryuichi Sugiyama; Zhiyu Yuan; Masamichi Muramatsu; Linghua Li
Journal:  J Biol Chem       Date:  2019-07-30       Impact factor: 5.157

3.  Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.

Authors:  Alexander A Kukreja; Joseph C-Y Wang; Elizabeth Pierson; David Z Keifer; Lisa Selzer; Zhenning Tan; Bogdan Dragnea; Martin F Jarrold; Adam Zlotnick
Journal:  J Virol       Date:  2014-09-24       Impact factor: 5.103

4.  Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.

Authors:  Xiaolin Li; Kai Zhou; Haiying He; Qiong Zhou; Ya Sun; Lijuan Hou; Liang Shen; Xiaofei Wang; Yuedong Zhou; Zhen Gong; Shibo He; Huangtao Jin; Zhengxian Gu; Shuyong Zhao; Long Zhang; Chunyan Sun; Shansong Zheng; Zhe Cheng; Yidong Zhu; Minghui Zhang; Jian Li; Shuhui Chen
Journal:  ACS Med Chem Lett       Date:  2017-08-24       Impact factor: 4.345

5.  Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells.

Authors:  Yuntao Bing; Siying Zhu; Guozheng Yu; Ting Li; Weijun Liu; Changsheng Li; Yitao Wang; Haolong Qi; Tao Guo; Yufeng Yuan; Yueming He; Zhisu Liu; Quanyan Liu
Journal:  J Biol Chem       Date:  2014-09-30       Impact factor: 5.157

6.  Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Authors:  Mark N Prichard; Debra C Quenelle; Caroll B Hartline; Emma A Harden; Geraldine Jefferson; Samuel L Frederick; Shannon L Daily; Richard J Whitley; Kamal N Tiwari; Joseph A Maddry; John A Secrist; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

7.  Understanding the molecular basis of HBV drug resistance by molecular modeling.

Authors:  Ashoke Sharon; Chung K Chu
Journal:  Antiviral Res       Date:  2008-08-31       Impact factor: 5.970

8.  Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.

Authors:  E Matthes; H Bünger
Journal:  Antimicrob Agents Chemother       Date:  2009-11-16       Impact factor: 5.191

9.  Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9.

Authors:  Chun-Chi Chen; Cheng-Pu Sun; Hsin-I Ma; Cheng-Chieh Fang; Pin-Yi Wu; Xiao Xiao; Mi-Hua Tao
Journal:  Mol Ther       Date:  2008-12-09       Impact factor: 11.454

10.  Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Authors:  Eisuke Murakami; Tatiana Tolstykh; Haiying Bao; Congrong Niu; Holly M Micolochick Steuer; Donghui Bao; Wonsuk Chang; Christine Espiritu; Shalini Bansal; Angela M Lam; Michael J Otto; Michael J Sofia; Phillip A Furman
Journal:  J Biol Chem       Date:  2010-08-26       Impact factor: 5.157
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