Literature DB >> 17966070

Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.

Yang Zhao1, Lu Wang, Hong-Bing Shen, Zhong-Xu Wang, Qing-Yi Wei, Feng Chen.   

Abstract

A meta-regression analysis was undertaken to evaluate the association between delta-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61 microg/dl. Using a random effects model, the pooled estimate was also significant at 1.51 microg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.

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Year:  2007        PMID： 17966070     DOI： 10.1080/15287390701550946

Source DB:  PubMed          Journal:  J Toxicol Environ Health A        ISSN： 0098-4108


  13 in total

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