Literature DB >> 17965721

B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

Chengyang Liu1, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, Zhonglin Wang, Michelle E Paessler, Ergun Velidedeoglu, Susan Y Rostami, Ming Yu, Clyde F Barker, Ali Naji.   

Abstract

We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.

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Year:  2007        PMID： 17965721     DOI： 10.1038/nm1673

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  79 in total

Review 1.  T-cell activation and transplantation tolerance.

Authors:  Bhavana Priyadharshini; Dale L Greiner; Michael A Brehm
Journal:  Transplant Rev (Orlando)       Date:  2011-11-08       Impact factor: 3.943

2.  Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model.

Authors:  Chengyang Liu; Brigitte Koeberlein; Michael D Feldman; Rebecca Mueller; Zhonglin Wang; Yanjing Li; Kristin Lane; Clifford C Hoyt; John E Tomaszewski; Ali Naji; Michael R Rickels
Journal:  Endocrinology       Date:  2012-02-21       Impact factor: 4.736

Review 3.  State of the art of clinical islet transplantation and novel protocols of immunosuppression.

Authors:  A M James Shapiro
Journal:  Curr Diab Rep       Date:  2011-10       Impact factor: 4.810

4.  Identification of a B cell signature associated with renal transplant tolerance in humans.

Authors:  Kenneth A Newell; Adam Asare; Allan D Kirk; Trang D Gisler; Kasia Bourcier; Manikkam Suthanthiran; William J Burlingham; William H Marks; Ignacio Sanz; Robert I Lechler; Maria P Hernandez-Fuentes; Laurence A Turka; Vicki L Seyfert-Margolis
Journal:  J Clin Invest       Date:  2010-05-24       Impact factor: 14.808

Review 5.  Comparative genomics of the human, macaque and mouse major histocompatibility complex.

Authors:  Takashi Shiina; Antoine Blancher; Hidetoshi Inoko; Jerzy K Kulski
Journal:  Immunology       Date:  2016-07-10       Impact factor: 7.397

6.  Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance.

Authors:  Girdhari Lal; Yumi Nakayama; Apoorva Sethi; Amit K Singh; Bryna E Burrell; Neeraja Kulkarni; C Colin Brinkman; Daiki Iwami; Tianshu Zhang; Jonathan S Bromberg
Journal:  Transplantation       Date:  2015-09       Impact factor: 4.939

7.  Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys.

Authors:  Shahrooz S Kelishadi; Agnes M Azimzadeh; Tianshu Zhang; Tiffany Stoddard; Emily Welty; Christopher Avon; Mitch Higuchi; Amal Laaris; Xiang-Fei Cheng; Christine McMahon; Richard N Pierson
Journal:  J Clin Invest       Date:  2010-03-24       Impact factor: 14.808

8.  Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease.

Authors:  Stefanie Sarantopoulos; Kristen E Stevenson; Haesook T Kim; Whitney S Washel; Nazmim S Bhuiya; Corey S Cutler; Edwin P Alyea; Vincent T Ho; Robert J Soiffer; Joseph H Antin; Jerome Ritz
Journal:  Blood       Date:  2010-11-19       Impact factor: 22.113

Review 9.  Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases.

Authors:  Jinsha Liu; Joey Paolo Ting; Shams Al-Azzam; Yun Ding; Sepideh Afshar
Journal:  Int J Mol Sci       Date:  2021-03-10       Impact factor: 5.923

10.  Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.

Authors:  Antonio Fontanellas; Sandra Hervás-Stubbs; Itsaso Mauleón; Juan Dubrot; Uxua Mancheño; María Collantes; Ana Sampedro; Carmen Unzu; Carlos Alfaro; Asis Palazón; Cristian Smerdou; Alberto Benito; Jesús Prieto; Iván Peñuelas; Ignacio Melero
Journal:  Mol Ther       Date:  2010-01-19       Impact factor: 11.454
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