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Literature DB >> 17965637

BLIMP1 guides the fate of effector B and T cells.

Stephen L Nutt¹, Kirsten A Fairfax, Axel Kallies.

Abstract

B-lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor, and its importance in controlling the terminal differentiation of antibody-secreting cells (ASCs) is well established. However, as we discuss in this Progress article, it has now become evident that the ASC programme consists of a discrete BLIMP1-independent initiation phase, followed by a second step in which BLIMP1 is absolutely required for the differentiation of fully mature ASCs. In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells.

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Year: 2007 PMID： 17965637 DOI： 10.1038/nri2204

Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106

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Cited

52 in total

1. CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.

Authors: Stéphane Chevrier; Céline Genton; Axel Kallies; Alexander Karnowski; Luc A Otten; Bernard Malissen; Marie Malissen; Marina Botto; Lynn M Corcoran; Stephen L Nutt; Hans Acha-Orbea
Journal: Proc Natl Acad Sci U S A Date: 2009-02-19 Impact factor: 11.205

2. Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation.

Authors: Shinu John; Lisa Russell; Shu Shien Chin; Wei Luo; Robert Oshima; Lee Ann Garrett-Sinha
Journal: Mol Cell Biol Date: 2013-11-25 Impact factor: 4.272

3. Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Authors: Ankit Mahendra; Xingyu Yang; Shaza Abnouf; Jay R T Adolacion; Daechan Park; Sanam Soomro; Jason Roszik; Cristian Coarfa; Gabrielle Romain; Keith Wanzeck; S Louis Bridges; Amita Aggarwal; Peng Qiu; Sandeep K Agarwal; Chandra Mohan; Navin Varadarajan
Journal: Arthritis Rheumatol Date: 2019-02-23 Impact factor: 10.995

4. Maturation of effector regulatory T cells.

Authors: Naganari Ohkura; Shimon Sakaguchi
Journal: Nat Immunol Date: 2011-04 Impact factor: 25.606

5. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.

Authors: Erika Cretney; Annie Xin; Wei Shi; Martina Minnich; Frederick Masson; Maria Miasari; Gabrielle T Belz; Gordon K Smyth; Meinrad Busslinger; Stephen L Nutt; Axel Kallies
Journal: Nat Immunol Date: 2011-03-06 Impact factor: 25.606

BLIMP1 guides the fate of effector B and T cells.

1. CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.

2. Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation.

3. Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

4. Maturation of effector regulatory T cells.

5. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.

Review 6. The generation of antibody-secreting plasma cells.

Review 7. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.

Review 8. Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Review 9. Expansion or depletion of T follicular helper cells during HIV infection: consequences for B cell responses.

10. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation.