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Literature DB >> 17965611

The Odyssey of MeCP2 and parental imprinting.

Abstract

DNA methylation in mammals has long been implicated in the epigenetic mechanism of parental imprinting, in which selective expression of one allele of specific genes is based on parental origin. Methyl CpG binding protein 2 (MeCP2) selectively binds to methylated DNA and mutations in the MECP2 cause the autism-spectrum neurodevelopmental disorder Rett syndrome. This review outlines the emerging story of how MeCP2 has been implicated in the regulation of specific imprinted genes and loci, including UBE3A and DLX5. The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process.

Entities: Disease Gene

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Year: 2006 PMID： 17965611 PMCID： PMC1866173 DOI： 10.4161/epi.2.1.3697

Source DB: PubMed Journal: Epigenetics ISSN： 1559-2294 Impact factor: 4.528

94 in total

1. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

Authors: Francois Fuks; Paul J Hurd; Daniel Wolf; Xinsheng Nan; Adrian P Bird; Tony Kouzarides
Journal: J Biol Chem Date: 2002-11-09 Impact factor: 5.157

2. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.

Authors: B Hendrich; J Guy; B Ramsahoye; V A Wilson; A Bird
Journal: Genes Dev Date: 2001-03-15 Impact factor: 11.361

3. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

Authors: Robert J Klose; Shireen A Sarraf; Lars Schmiedeberg; Suzanne M McDermott; Irina Stancheva; Adrian P Bird
Journal: Mol Cell Date: 2005-09-02 Impact factor: 17.970

Review 4. Methyl-CpG-binding protein 2 mutations in Rett syndrome.

Authors: I B Van den Veyver; H Y Zoghbi
Journal: Curr Opin Genet Dev Date: 2000-06 Impact factor: 5.578

5. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.

Authors: J Guy; B Hendrich; M Holmes; J E Martin; A Bird
Journal: Nat Genet Date: 2001-03 Impact factor: 38.330

6. Allele-specific replication timing of imprinted gene regions.

Authors: D Kitsberg; S Selig; M Brandeis; I Simon; I Keshet; D J Driscoll; R D Nicholls; H Cedar
Journal: Nature Date: 1993-07-29 Impact factor: 49.962

7. Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.

Authors: C Y Howell; T H Bestor; F Ding; K E Latham; C Mertineit; J M Trasler; J R Chaillet
Journal: Cell Date: 2001-03-23 Impact factor: 41.582

8. MECP2 mutation in male patients with non-specific X-linked mental retardation.

Authors: A Orrico; C Lam; L Galli; M T Dotti; G Hayek; S F Tong; P M Poon; M Zappella; A Federico; V Sorrentino
Journal: FEBS Lett Date: 2000-09-22 Impact factor: 4.124

9. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.

Authors: Shin-ichi Horike; Shutao Cai; Masaru Miyano; Jan-Fang Cheng; Terumi Kohwi-Shigematsu
Journal: Nat Genet Date: 2004-12-19 Impact factor: 38.330

10. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

Authors: Qiang Chang; Gargi Khare; Vardhan Dani; Sacha Nelson; Rudolf Jaenisch
Journal: Neuron Date: 2006-02-02 Impact factor: 17.173

12 in total

Review 1. Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.

Authors: John L R Rubenstein
Journal: J Child Psychol Psychiatry Date: 2010-08-24 Impact factor: 8.982

2. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.

Authors: Alexander H Joyner; Cooper Roddey J; Cinnamon S Bloss; Trygve E Bakken; Lars M Rimol; Ingrid Melle; Ingrid Agartz; Srdjan Djurovic; Eric J Topol; Nicholas J Schork; Ole A Andreassen; Anders M Dale
Journal: Proc Natl Acad Sci U S A Date: 2009-08-26 Impact factor: 11.205

The Odyssey of MeCP2 and parental imprinting.

1. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

2. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.

3. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

Review 4. Methyl-CpG-binding protein 2 mutations in Rett syndrome.

5. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.

6. Allele-specific replication timing of imprinted gene regions.

7. Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.

8. MECP2 mutation in male patients with non-specific X-linked mental retardation.

9. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.

10. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

Review 1. Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.

2. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.

3. Evidence for alterations in stimulatory G proteins and oxytocin levels in children with autism.

4. Chromatin modifiers, cognitive disorders, and imprinted genes.

Review 5. Diet and the epigenetic (re)programming of phenotypic differences in behavior.

Review 6. MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness.

7. Methyl-CpG-binding protein 2 polymorphisms and vulnerability to autism.

Review 8. Noncoding RNAs in mental retardation.

9. Blood mercury concentrations in CHARGE Study children with and without autism.

10. A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.