Literature DB >> 17965559

Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis.

Katsumi Fukino1, Tomoe Kawashima, Masahiko Suzuki, Koichi Ueno.   

Abstract

We investigated the genotypes of methylenetetrahydrofolate reductase (MTHFR) and reduced folate carrier-1 (RFC-1), and the serum concentrations of methotrexate (MTX) in 100 outpatients with rheumatoid arthritis (RA). Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States. No correlations were found between these genotypes and serum MTX levels.

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Year:  2007        PMID： 17965559     DOI： 10.2131/jts.32.449

Source DB:  PubMed          Journal:  J Toxicol Sci        ISSN： 0388-1350            Impact factor:   2.196


  5 in total

1.  Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.

Authors:  Ravi Ramalingam; Harpreet Kaur; Julius Xavier Scott; Latha M Sneha; Ganeshprasad Arunkumar; Arathi Srinivasan; Solomon F D Paul
Journal:  Cancer Chemother Pharmacol       Date:  2022-02-14       Impact factor: 3.333

2.  Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population.

Authors:  Masayuki Hashiguchi; Mikiko Shimizu; Jun Hakamata; Tomomi Tsuru; Takanori Tanaka; Midori Suzaki; Kumika Miyawaki; Takeshi Chiyoda; Osamu Takeuchi; Jiro Hiratsuka; Shin Irie; Junya Maruyama; Mayumi Mochizuki
Journal:  J Pharm Health Care Sci       Date:  2016-12-09

3.  Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.

Authors:  S A Owen; S L Hider; P Martin; I N Bruce; A Barton; W Thomson
Journal:  Pharmacogenomics J       Date:  2012-03-27       Impact factor: 3.550

4.  Pharmacogenomics of Methotrexate Pathway in Rheumatoid Arthritis Patients: Approach toward Personalized Medicine.

Authors:  Hoda Y Abdallah; Maha E Ibrahim; Noha M Abd El-Fadeal; Dina A Ali; Gehad G Elsehrawy; Rasha E Badr; Howayda M Hassoba
Journal:  Diagnostics (Basel)       Date:  2022-06-27

5.  MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.

Authors:  Mirna Gisel González-Mercado; Fernando Rivas; M Patricia Gallegos-Arreola; M Cristina Morán-Moguel; Mario Salazar-Páramo; Laura González-López; J Iván Gámez-Nava; J Francisco Muñoz-Valle; Ricardo Medina-Coss Y León; Anahí González-Mercado; Mario A Aceves; Nory O Dávalos; Agustín Macías-Chumacera; Ingrid P Dávalos
Journal:  Genet Test Mol Biomarkers       Date:  2017-10-10
  5 in total

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