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Literature DB >> 17965482

A novel ansamycin, naphthomycin K from Streptomyces sp.

Abstract

One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17965482 DOI： 10.1038/ja.2007.84

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

12 in total

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6. Endophytic Actinobacteria Associated with Dracaena cochinchinensis Lour.: Isolation, Diversity, and Their Cytotoxic Activities.

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A novel ansamycin, naphthomycin K from Streptomyces sp.

Review 1. Leveraging ecological theory to guide natural product discovery.

Review 2. Microbial natural products: molecular blueprints for antitumor drugs.

3. Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China.

4. Plant-derived bioactive compounds produced by Streptomyces variabilis LCP18 associated with Litsea cubeba (Lour.) Pers as potential target to combat human pathogenic bacteria and human cancer cell lines.

Review 5. Endophytic actinobacteria of medicinal plants: diversity and bioactivity.

6. Endophytic Actinobacteria Associated with Dracaena cochinchinensis Lour.: Isolation, Diversity, and Their Cytotoxic Activities.

Review 7. Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes.

Review 8. Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches.

Review 9. Impact of endophytic microorganisms on plants, environment and humans.

Review 10. The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies.