Mathematical modeling of cell migration.

Mathematical modeling has become increasingly important in many areas of biology during the past two decades, and the area of cell migration and motility has seen significant contributions from a wide range of modeling approaches. In this chapter, we cover examples from the broad range of work in this area, emphasizing the models' biological significance and the relationships between them. We focus on three specific areas: cell protrusion, cell adhesion, and retraction/whole-cell models. At the end of this chapter, we provide our perspective on issues that future models and experiments should consider in order to advance the boundaries of this field.