| Literature DB >> 17964794 |
Peter Jan Zimmermann1, Christof Brehm, Wilm Buhr, Andreas Marc Palmer, Jürgen Volz, Wolfgang-Alexander Simon.
Abstract
A series of novel 6-substituted imidazo[1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H(+)/K(+)-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.Entities:
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Year: 2007 PMID： 17964794 DOI： 10.1016/j.bmc.2007.09.009
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641