| Literature DB >> 17964172 |
Tina Korosec1, Jure Acimovic, Matej Seliskar, Darko Kocjan, Klementina Fon Tacer, Damjana Rozman, Uros Urleb.
Abstract
Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14alpha-demethylase (CYP51). Structure-activity relationship study of the binding with the overexpressed human CYP51 indicates that the pyridine binds within the heme binding pocket in an analogy with the azoles.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17964172 DOI： 10.1016/j.bmc.2007.10.001
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641