| Literature DB >> 17964072 |
Rojsanga Piyanuch1, Mugdha Sukhthankar, Gritsanapan Wandee, Seung Joon Baek.
Abstract
Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis.Entities:
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Year: 2007 PMID： 17964072 PMCID： PMC2171032 DOI： 10.1016/j.canlet.2007.09.007
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679