BACKGROUND: Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A and rs6318 (Cys23Ser) of HTR2C have been investigated in suicide behavior in other studies. METHODS: Here, we investigated rs6313 and rs6318 and other 10 randomly chosen SNPs, of those three genes in a study of 329 psychiatric patients who had never attempted suicide and 297 patients who had attempted suicide. RESULTS: No associations were found for the 12 SNPS. CONCLUSIONS: Our results do not support the involvement of HTR2A, 5HTT or HTR2C in suicidal behavior in Han Chinese subjects.
BACKGROUND: Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A and rs6318 (Cys23Ser) of HTR2C have been investigated in suicide behavior in other studies. METHODS: Here, we investigated rs6313 and rs6318 and other 10 randomly chosen SNPs, of those three genes in a study of 329 psychiatricpatients who had never attempted suicide and 297 patients who had attempted suicide. RESULTS: No associations were found for the 12 SNPS. CONCLUSIONS: Our results do not support the involvement of HTR2A, 5HTT or HTR2C in suicidal behavior in Han Chinese subjects.
Authors: Vasileios Boulougouris; Ioannis Malogiannis; George Lockwood; Iannis Zervas; Giuseppe Di Giovanni Journal: Exp Brain Res Date: 2013-08-23 Impact factor: 1.972
Authors: Gabriel Molina-Guzman; Thelma Beatriz González-Castro; Yazmín Hernández Díaz; Carlos Alfonso Tovilla-Zárate; Isela E Juárez-Rojop; Crystell Guadalupe Guzmán-Priego; Alma Genis; Sherezada Pool García; María Lilia López-Narvaez; José Manuel Rodriguez-Perez Journal: Neuropsychiatr Dis Treat Date: 2017-02-22 Impact factor: 2.570
Authors: Marta Sadkowski; Brittany Dennis; Robert C Clayden; Wala Elsheikh; Sumathy Rangarajan; Jane Dejesus; Zainab Samaan Journal: Neuropsychiatr Dis Treat Date: 2013-11-06 Impact factor: 2.570