OBJECTIVE: To investigate the impact of inherited thrombophilic factors on the gestational outcome of unselected pregnant women. METHOD: A total of 392 women with spontaneous pregnancy were investigated for Factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations. Adverse pregnancy outcomes were recorded. RESULTS: Thrombophilic genotypes were significantly higher in women with placental abruption. Heterozygocity for Factor V Leiden increased the risk for placental abruption 9.1 times. The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels. Women with inherited thrombophilia and previous obstetric complications were at significant risk for complications in a subsequent pregnancy (P<0.05). CONCLUSION: Women with placental abruption should be screened for thrombophilic factors and plasma homocysteine should be measured. Subgroups of women with inherited thrombophilia and obstetric complications might benefit from prophylactic anticoagulation in subsequent pregnancies.
OBJECTIVE: To investigate the impact of inherited thrombophilic factors on the gestational outcome of unselected pregnant women. METHOD: A total of 392 women with spontaneous pregnancy were investigated for Factor V Leiden, prothrombin G20210A, and MTHFRC677T mutations. Adverse pregnancy outcomes were recorded. RESULTS:Thrombophilic genotypes were significantly higher in women with placental abruption. Heterozygocity for Factor V Leiden increased the risk for placental abruption 9.1 times. The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels. Women with inherited thrombophilia and previous obstetric complications were at significant risk for complications in a subsequent pregnancy (P<0.05). CONCLUSION:Women with placental abruption should be screened for thrombophilic factors and plasma homocysteine should be measured. Subgroups of women with inherited thrombophilia and obstetric complications might benefit from prophylactic anticoagulation in subsequent pregnancies.
Authors: Tormod Rogne; Myrte J Tielemans; Mary Foong-Fong Chong; Chittaranjan S Yajnik; Ghattu V Krishnaveni; Lucilla Poston; Vincent W V Jaddoe; Eric A P Steegers; Suyog Joshi; Yap-Seng Chong; Keith M Godfrey; Fabian Yap; Raquel Yahyaoui; Tinku Thomas; Gry Hay; Marije Hogeveen; Ahmet Demir; Ponnusamy Saravanan; Eva Skovlund; Marit P Martinussen; Geir W Jacobsen; Oscar H Franco; Michael B Bracken; Kari R Risnes Journal: Am J Epidemiol Date: 2017-02-01 Impact factor: 4.897
Authors: Marc A Rodger; Marisol T Betancourt; Peter Clark; Pelle G Lindqvist; Donna Dizon-Townson; Joanne Said; Uri Seligsohn; Marc Carrier; Ophira Salomon; Ian A Greer Journal: PLoS Med Date: 2010-06-15 Impact factor: 11.069
Authors: Julia Warner Gargano; Claudia B Holzman; Patricia K Senagore; M Lynne Reuss; Dorothy R Pathak; Karen H Friderici; Katherine Jernigan; Rachel Fisher Journal: Am J Obstet Gynecol Date: 2009-09 Impact factor: 8.661