| Literature DB >> 17963733 |
Angelo C Lepore1, Christine Haenggeli, Mehdi Gasmi, Kathie M Bishop, Raymond T Bartus, Nicholas J Maragakis, Jeffrey D Rothstein.
Abstract
The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of amyotrophic lateral sclerosis (ALS). In an effort to maximize rate of motor neuron transduction, achieve high levels of spinal IGF-1 and thus enhance therapeutic benefit, we injected an adeno-associated virus 2 (AAV2)-based vector encoding human IGF-1 (CERE-130) into lumbar spinal cord parenchyma of SOD1(G93A) mice. We observed robust and long-term intraspinal IGF-1 expression and partial rescue of lumbar spinal cord motor neurons, as well as sex-specific delayed disease onset, weight loss, decline in hindlimb grip strength and increased animal survival.Entities:
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Year: 2007 PMID： 17963733 PMCID： PMC2265207 DOI： 10.1016/j.brainres.2007.09.034
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252