Literature DB >> 17962783

A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution.

Freddy Tjosaas1, Anne Fiksdahl.   

Abstract

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.

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Year:  2006        PMID： 17962783      PMCID： PMC6148553          DOI： 10.3390/11020130

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  1 in total

1.  Tetrabutylammonium salt induced denitration of nitropyridines: synthesis of fluoro-, hydroxy-, and methoxypyridines.

Authors:  Scott D Kuduk; Robert M DiPardo; Mark G Bock
Journal:  Org Lett       Date:  2005-02-17       Impact factor: 6.005
  1 in total
  1 in total

1.  An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement.

Authors:  Falguni Basuli; Xiang Zhang; Pedro Brugarolas; Daniel S Reich; Rolf E Swenson
Journal:  J Labelled Comp Radiopharm       Date:  2017-11-30       Impact factor: 1.921
  1 in total

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