| Literature DB >> 17962772 |
Hongxia He1, Mengjia Liu, Zhibing Zheng, Ying Liu, Junhai Xiao, Ruibin Su, Chun Hu, Jin Li, Song Li.
Abstract
A series of N,N'-disubstituted-2-nitroethene-1,1-diamine and N,N'-disubstituted- N''-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.Entities:
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Year: 2006 PMID： 17962772 PMCID： PMC6148528 DOI： 10.3390/11060393
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411