Literature DB >> 17962771

Synthesis and antifungal bioactivities of 3-alkylquinazolin- 4-one derivatives.

Guiping Ouyang1, Peiquan Zhang, Gangfang Xu, Baoan Song, Song Yang, Linhong Jin, Wei Xue, Deyu Hu, Ping Lu, Zhuo Chen.   

Abstract

A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

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Year:  2006        PMID： 17962771      PMCID： PMC6148534          DOI： 10.3390/11060383

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  4 in total

1.  Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors.

Authors:  Yi Jin; Hui-Yuan Li; Li-Ping Lin; Jinzhi Tan; Jian Ding; Xiaomin Luo; Ya-Qiu Long
Journal:  Bioorg Med Chem       Date:  2005-10-01       Impact factor: 3.641

2.  Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

Authors:  Q Chao; L Deng; H Shih; L M Leoni; D Genini; D A Carson; H B Cottam
Journal:  J Med Chem       Date:  1999-09-23       Impact factor: 7.446

3.  4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

Authors:  A Wissner; D M Berger; D H Boschelli; M B Floyd; L M Greenberger; B C Gruber; B D Johnson; N Mamuya; R Nilakantan; M F Reich; R Shen; H R Tsou; E Upeslacis; Y F Wang; B Wu; F Ye; N Zhang
Journal:  J Med Chem       Date:  2000-08-24       Impact factor: 7.446

4.  Structure-activity relationships of 6-fluoroquinazolines: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.

Authors:  Masanori Tobe; Yoshiaki Isobe; Hideyuki Tomizawa; Takahiro Nagasaki; Fumihiro Obara; Hideya Hayashi
Journal:  Bioorg Med Chem       Date:  2003-02-20       Impact factor: 3.641
  4 in total
  5 in total

1.  Synthesis and antiviral bioactivities of 2-aryl- or 2-methyl-3-(substituted- benzalamino)-4(3H)-quinazolinone derivatives.

Authors:  Xingwen Gao; Xuejian Cai; Kai Yan; Baoan Song; Lili Gao; Zhuo Chen
Journal:  Molecules       Date:  2007-12-27       Impact factor: 4.411

2.  Synthesis and analgesic activity of some new pyrazoles and triazoles bearing a 6,8-dibromo-2-methylquinazoline moiety.

Authors:  Hosam A Saad; Nermen A Osman; Ahmed H Moustafa
Journal:  Molecules       Date:  2011-12-07       Impact factor: 4.411

3.  Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives.

Authors:  G A Khodarahmi; M Rahmani Khajouei; G H Hakimelahi; D Abedi; E Jafari; F Hassanzadeh
Journal:  Res Pharm Sci       Date:  2012-07

4.  Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one.

Authors:  K K Sivakumar; A Rajasekharan; R Rao; B Narasimhan
Journal:  Indian J Pharm Sci       Date:  2013-07       Impact factor: 0.975

5.  Synthesis, Spectroscopic Characterization, and Time-Dependent DFT Calculations of 1-Methyl-5-phenyl-5H-pyrido[1,2-a]quinazoline-3,6-dione and Its Starting Precursor in Different Solvents.

Authors:  Nagwa M M Hamada
Journal:  ChemistryOpen       Date:  2018-10-12       Impact factor: 2.911
  5 in total

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