Literature DB >> 17962767

Synthesis of novel sterically demanding carbo- and heterocyclic beta-ketoesters.

Marko D Mihovilovic1, Thomas C M Fischer, Peter Stanetty.   

Abstract

We present an easy method for the synthesis of beta-ketoesters starting from various carbocyclic and heterocyclic carboxylic acids and esters. The beta-ketoester side-chain was introduced by a sequence involving alpha-deprotonation and quenching with CO(2), conversion to the corresponding acid chloride and subsequent chain elongation using deprotonated ethyl acetate.

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Year:  2006        PMID： 17962767      PMCID： PMC6148537          DOI： 10.3390/11050357

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  3 in total

1.  Conformationally restricted paclitaxel analogues: macrocyclic mimics of the "hydrophobic collapse" conformation.

Authors:  T C Boge; Z J Wu; R H Himes; D G Vander Velde; G I Georg
Journal:  Bioorg Med Chem Lett       Date:  1999-10-18       Impact factor: 2.823

2.  Studies on the total synthesis of (-)-CP-263,114.

Authors:  Takehiko Yoshimitsu; Shuji Sasaki; Yoshimasa Arano; Hiroto Nagaoka
Journal:  J Org Chem       Date:  2004-12-24       Impact factor: 4.354

3.  Enantiodivergent, biocatalytic routes to both taxol side chain antipodes.

Authors:  Brent D Feske; Iwona A Kaluzna; Jon D Stewart
Journal:  J Org Chem       Date:  2005-11-11       Impact factor: 4.354
  3 in total

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