Literature DB >> 17962758

Microwave assisted synthesis of N-arylheterocyclic substituted-4-aminoquinazoline derivatives.

Gang Liu1, Song Yang, Baoan Song, Wei Xue, Deyu Hu, Linhong Jin, Ping Lu.   

Abstract

A simple, efficient, and general method has been developed for the synthesis of various N-aryl heterocylic substituted-4-aminoquinazoline compounds from 4-chloro- quinazoline and aryl heterocyclic amines under microwave irradiation using 2-propanol as solvent. The advantages of the use of microwave irradiation in relation to the classical method were demonstrated.

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Year:  2006        PMID： 17962758      PMCID： PMC6148531          DOI： 10.3390/11040272

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  12 in total

1.  1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase.

Authors:  J Y Lee; Y K Park; S H Seo; I S So; H K Chung; B S Yang; S J Lee; H Park; Y S Lee
Journal:  Arch Pharm (Weinheim)       Date:  2001-11       Impact factor: 3.751

2.  Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.

Authors:  A Rosowsky; A T Papoulis; R A Forsch; S F Queener
Journal:  J Med Chem       Date:  1999-03-25       Impact factor: 7.446

Review 3.  The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.

Authors:  A L Jackman; R Kimbell; M Brown; L Brunton; K R Harrap; J M Wardleworth; F T Boyle
Journal:  Adv Exp Med Biol       Date:  1994       Impact factor: 2.622

4.  Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).

Authors:  C M Discafani; M L Carroll; M B Floyd; I J Hollander; Z Husain; B D Johnson; D Kitchen; M K May; M S Malo; A A Minnick; R Nilakantan; R Shen; Y F Wang; A Wissner; L M Greenberger
Journal:  Biochem Pharmacol       Date:  1999-04-15       Impact factor: 5.858

5.  Quinazoline derivatives; the synthesis of 4-(4'-diethylamino-1'-methylbutylamino)-quinazoline (SN 11,534) and the corresponding 2-phenylquinazoline (SN 11,535).

Authors:  M M ENDICOTT; E WICK
Journal:  J Am Chem Soc       Date:  1946-07       Impact factor: 15.419

6.  4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

Authors:  A Wissner; D M Berger; D H Boschelli; M B Floyd; L M Greenberger; B C Gruber; B D Johnson; N Mamuya; R Nilakantan; M F Reich; R Shen; H R Tsou; E Upeslacis; Y F Wang; B Wu; F Ye; N Zhang
Journal:  J Med Chem       Date:  2000-08-24       Impact factor: 7.446

7.  Structure-activity relationships of 6-fluoroquinazolines: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.

Authors:  Masanori Tobe; Yoshiaki Isobe; Hideyuki Tomizawa; Takahiro Nagasaki; Fumihiro Obara; Hideya Hayashi
Journal:  Bioorg Med Chem       Date:  2003-02-20       Impact factor: 3.641

8.  Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Authors:  R J Griffin; S Srinivasan; K Bowman; A H Calvert; N J Curtin; D R Newell; L C Pemberton; B T Golding
Journal:  J Med Chem       Date:  1998-12-17       Impact factor: 7.446

9.  Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.

Authors:  A Gangjee; N Zaveri; M Kothare; S F Queener
Journal:  J Med Chem       Date:  1995-09-01       Impact factor: 7.446

10.  Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Authors:  G W Rewcastle; B D Palmer; A J Bridges; H D Showalter; L Sun; J Nelson; A McMichael; A J Kraker; D W Fry; W A Denny
Journal:  J Med Chem       Date:  1996-02-16       Impact factor: 7.446
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  4 in total

1.  Synthesis and antimicrobial evaluation of novel 1,2,4-triazole thioether derivatives bearing a quinazoline moiety.

Authors:  Zhijiang Fan; Jun Shi; Xiaoping Bao
Journal:  Mol Divers       Date:  2018-03-24       Impact factor: 2.943

2.  Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids.

Authors:  Guirong Qu; Zhiguang Zhang; Haiming Guo; Mingwei Geng; Ran Xia
Journal:  Molecules       Date:  2007-03-19       Impact factor: 4.411

3.  Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents.

Authors:  Rodolfo H V Nishimura; Thiago Dos Santos; Valter E Murie; Luciana C Furtado; Leticia V Costa-Lotufo; Giuliano C Clososki
Journal:  Beilstein J Org Chem       Date:  2021-12-22       Impact factor: 2.883

4.  Rapid synthesis and antiviral activity of (quinazolin-4-ylamino)methyl-phosphonates through microwave irradiation.

Authors:  Hui Luo; Deyu Hu; Jian Wu; Ming He; Linhong Jin; Song Yang; Baoan Song
Journal:  Int J Mol Sci       Date:  2012-06-01       Impact factor: 6.208
  4 in total

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