| Literature DB >> 17961824 |
Junguk Park1, Reshma Jagasia, Gunnar F Kaufmann, John C Mathison, Diana I Ruiz, Jason A Moss, Michael M Meijler, Richard J Ulevitch, Kim D Janda.
Abstract
Quorum sensing (QS) is the process through which bacteria communicate utilizing small diffusible molecules termed autoinducers. It has been demonstrated that QS controls a plethora of microbial processes including the expression of virulence factors. Here we report an immunopharmacotherapeutic approach for the attenuation of QS in the Gram-positive human pathogen Staphylococcus aureus. An anti-autoinducer monoclonal antibody, AP4-24H11, was elicited against a rationally designed hapten, and efficiently inhibited QS in vitro through the sequestration of the autoinducing peptide (AIP)-4 produced by S. aureus RN4850. Importantly, AP4-24H11 suppressed S. aureus pathogenicity in an abscess formation mouse model in vivo and provided complete protection against a lethal S. aureus challenge. These findings provide a strong foundation for further investigations of immunopharmacotherapy for the treatment of bacterial infections in which QS controls the expression of virulence factors.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17961824 PMCID： PMC2088803 DOI： 10.1016/j.chembiol.2007.08.013
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521