OBJECTIVE: To explore sex differences in pediatric bipolar disorder in terms of subtype and severity of depressive and manic symptomatology. METHOD: Participants were 760 youth (aged 5-17 years) and their legal guardians. Participants were part of a larger outpatient assessment protocol enriched for bipolar disorder. Youth were assessed for DSM-IV diagnoses using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version. Their presenting mood state was determined using the Young Mania Rating Scale and the Children's Depression Rating Scale-Revised. The study was conducted from January 1996 to February 2003. RESULTS: 387 youth (51%) met DSM-IV criteria for diagnoses of bipolar spectrum disorders. Results showed no sex differences in rates of bipolar spectrum disorders or any of the bipolar subtypes. Sex differences were found with regard to presenting mood states: boys presented with higher rates of manic mood, and girls presented with higher rates of depressed mood. Older children were also more likely than younger children to exhibit higher levels of depressed mood. There were no age differences in levels of manic mood. CONCLUSION: This study highlights how bipolar disorder can manifest itself differently among girls and boys despite equivalent rates of diagnosis. It is important for clinicians to consider the full range of mood states in order to accurately diagnose and treat children. Future research is needed to assess the roles that genetics, puberty, cognitive styles, and environmental factors play in the expression of mania and depression in girls and boys over the course of their development.
OBJECTIVE: To explore sex differences in pediatric bipolar disorder in terms of subtype and severity of depressive and manic symptomatology. METHOD:Participants were 760 youth (aged 5-17 years) and their legal guardians. Participants were part of a larger outpatient assessment protocol enriched for bipolar disorder. Youth were assessed for DSM-IV diagnoses using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version. Their presenting mood state was determined using the Young Mania Rating Scale and the Children's Depression Rating Scale-Revised. The study was conducted from January 1996 to February 2003. RESULTS: 387 youth (51%) met DSM-IV criteria for diagnoses of bipolar spectrum disorders. Results showed no sex differences in rates of bipolar spectrum disorders or any of the bipolar subtypes. Sex differences were found with regard to presenting mood states: boys presented with higher rates of manic mood, and girls presented with higher rates of depressed mood. Older children were also more likely than younger children to exhibit higher levels of depressed mood. There were no age differences in levels of manic mood. CONCLUSION: This study highlights how bipolar disorder can manifest itself differently among girls and boys despite equivalent rates of diagnosis. It is important for clinicians to consider the full range of mood states in order to accurately diagnose and treat children. Future research is needed to assess the roles that genetics, puberty, cognitive styles, and environmental factors play in the expression of mania and depression in girls and boys over the course of their development.
Authors: Sarah McCue Horwitz; Christine A Demeter; Maria E Pagano; Eric A Youngstrom; Mary A Fristad; L Eugene Arnold; Boris Birmaher; Mary Kay Gill; David Axelson; Robert A Kowatch; Thomas W Frazier; Robert L Findling Journal: J Clin Psychiatry Date: 2010-10-05 Impact factor: 4.384
Authors: Stephanie Salcedo; Yen-Ling Chen; Eric A Youngstrom; Mary A Fristad; Kenneth D Gadow; Sarah M Horwitz; Thomas W Frazier; L Eugene Arnold; Mary L Phillips; Boris Birmaher; Robert A Kowatch; Robert L Findling Journal: J Clin Child Adolesc Psychol Date: 2017-03-02
Authors: Guillermo Pérez Algorta; Eric A Youngstrom; Thomas W Frazier; Andrew J Freeman; Jennifer Kogos Youngstrom; Robert L Findling Journal: Bipolar Disord Date: 2011-02 Impact factor: 6.744
Authors: Anthony T Vesco; Jennifer Lehmann; Barbara L Gracious; L Eugene Arnold; Andrea S Young; Mary A Fristad Journal: J Child Adolesc Psychopharmacol Date: 2015-08-19 Impact factor: 2.576
Authors: Janet Wozniak; Joseph Biederman; Mary Kate Martelon; Mariely Hernandez; K Yvonne Woodworth; Stephen V Faraone Journal: J Affect Disord Date: 2013-02-26 Impact factor: 4.839
Authors: June Gruber; Kirsten E Gilbert; Eric Youngstrom; Jennifer Kogos Youngstrom; Norah C Feeny; Robert L Findling Journal: J Abnorm Child Psychol Date: 2013-10