Literature DB >> 17960873

Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin.

Cherie L Stabler1, Xue-Long Sun, Wanxing Cui, John T Wilson, Carolyn A Haller, Elliot L Chaikof.   

Abstract

Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses.

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Year:  2007        PMID： 17960873     DOI： 10.1021/bc7002814

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  29 in total

1.  Chemoselective immobilization of peptides on abiotic and cell surfaces at controlled densities.

Authors:  Venkata R Krishnamurthy; John T Wilson; Wanxing Cui; XueZheng Song; Yi Lasanajak; Richard D Cummings; Elliot L Chaikof
Journal:  Langmuir       Date:  2010-06-01       Impact factor: 3.882

2.  Making a case: nanofabrication techniques in encapsulated cell therapy for people with diabetes.

Authors:  Barjor Gimi
Journal:  J Diabetes Sci Technol       Date:  2010-07-01

Review 3.  Enhancing clinical islet transplantation through tissue engineering strategies.

Authors:  Jaime A Giraldo; Jessica D Weaver; Cherie L Stabler
Journal:  J Diabetes Sci Technol       Date:  2010-09-01

4.  PEG-maleimide hydrogels for protein and cell delivery in regenerative medicine.

Authors:  Andrés J García
Journal:  Ann Biomed Eng       Date:  2013-07-24       Impact factor: 3.934

Review 5.  Bioengineered sites for islet cell transplantation.

Authors:  Sophie Vériter; Pierre Gianello; Denis Dufrane
Journal:  Curr Diab Rep       Date:  2013-10       Impact factor: 4.810

6.  Chemoselective cross-linking and functionalization of alginate via Staudinger ligation.

Authors:  Kerim M Gattás-Asfura; Cherie L Stabler
Journal:  Biomacromolecules       Date:  2009-11-09       Impact factor: 6.988

7.  End-point immobilization of recombinant thrombomodulin via sortase-mediated ligation.

Authors:  Rui Jiang; Jacob Weingart; Hailong Zhang; Yong Ma; Xue-Long Sun
Journal:  Bioconjug Chem       Date:  2012-03-08       Impact factor: 4.774

Review 8.  Nanotechnology in cell replacement therapies for type 1 diabetes.

Authors:  Alexander U Ernst; Daniel T Bowers; Long-Hai Wang; Kaavian Shariati; Mitchell D Plesser; Natalie K Brown; Tigran Mehrabyan; Minglin Ma
Journal:  Adv Drug Deliv Rev       Date:  2019-02-02       Impact factor: 15.470

9.  Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells.

Authors:  Veronika Kozlovskaya; Oleksandra Zavgorodnya; Yi Chen; Kristin Ellis; Hubert M Tse; Wanxing Cui; J Anthony Thompson; Eugenia Kharlampieva
Journal:  Adv Funct Mater       Date:  2012-04-30       Impact factor: 18.808

10.  Thrombosis and inflammation in intraportal islet transplantation: a review of pathophysiology and emerging therapeutics.

Authors:  John T Wilson; Elliot L Chaikof
Journal:  J Diabetes Sci Technol       Date:  2008-09
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