Use of combination therapy in migraine: a review of the clinical evidence.

The previous article in this supplement sets forth a compelling argument for use of multimechanism combination pharmacotherapy as a strategy to improve outcomes for patients with migraine. This article picks up where the previous one left off by providing a concise review of data regarding use of combined agents to treat migraine. Included in this review are clinical studies of both over-the-counter (OTC) and prescription agents whose performance in combination has been assessed in comparison to placebo and/or monotherapy. Also, this review is not limited to fixed drug combinations; studies that used different single-agent tablets administered together are also included.