Literature DB >> 17960590

Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.

Yanning Ding1, William J Brackenbury, Pinar U Onganer, Ximena Montano, Louise M Porter, Lucy F Bates, Mustafa B A Djamgoz.   

Abstract

The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activity. (c) 2007 Wiley-Liss, Inc.

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Year:  2008        PMID： 17960590      PMCID： PMC4122813          DOI： 10.1002/jcp.21289

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  53 in total

1.  Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na(+) channel expression in vitro.

Authors:  P U Onganer; M B A Djamgoz
Journal:  J Membr Biol       Date:  2005-03       Impact factor: 1.843

2.  Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.

Authors:  Scott P Fraser; James K J Diss; Athina-Myrto Chioni; Maria E Mycielska; Huiyan Pan; Rezan F Yamaci; Filippo Pani; Zuzanna Siwy; Monika Krasowska; Zbigniew Grzywna; William J Brackenbury; Dimis Theodorou; Meral Koyutürk; Handan Kaya; Esra Battaloglu; Manuela Tamburo De Bella; Martin J Slade; Robert Tolhurst; Carlo Palmieri; Jie Jiang; David S Latchman; R Charles Coombes; Mustafa B A Djamgoz
Journal:  Clin Cancer Res       Date:  2005-08-01       Impact factor: 12.531

3.  A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo.

Authors:  J K J Diss; D Stewart; F Pani; C S Foster; M M Walker; A Patel; M B A Djamgoz
Journal:  Prostate Cancer Prostatic Dis       Date:  2005       Impact factor: 5.554

4.  Growth factors in expressed prostatic fluid from men with prostate cancer, BPH, and clinically normal prostates.

Authors:  P H Gann; K G Klein; R T Chatterton; A E Ellman; J T Grayhack; R B Nadler; C Lee
Journal:  Prostate       Date:  1999-09-01       Impact factor: 4.104

5.  Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells.

Authors:  M Abdul; N Hoosein
Journal:  Anticancer Res       Date:  2001 May-Jun       Impact factor: 2.480

6.  Expression profiles of voltage-gated Na(+) channel alpha-subunit genes in rat and human prostate cancer cell lines.

Authors:  J K Diss; S N Archer; J Hirano; S P Fraser; M B Djamgoz
Journal:  Prostate       Date:  2001-08-01       Impact factor: 4.104

7.  Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.

Authors:  M E Laniado; E N Lalani; S P Fraser; J A Grimes; G Bhangal; M B Djamgoz; P D Abel
Journal:  Am J Pathol       Date:  1997-04       Impact factor: 4.307

8.  Patterning of endocytic vesicles and its control by voltage-gated Na+ channel activity in rat prostate cancer cells: fractal analyses.

Authors:  Monika Krasowska; Zbigniew J Grzywna; Maria E Mycielska; Mustafa B A Djamgoz
Journal:  Eur Biophys J       Date:  2004-03-16       Impact factor: 1.733

9.  Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activity.

Authors:  M Mycielska; Z Madeja; S P Fraser; W Korohoda
Journal:  J Cell Sci       Date:  2001-07       Impact factor: 5.285

Review 10.  Neuronal characteristics of small-cell lung cancer.

Authors:  P U Onganer; M J Seckl; M B A Djamgoz
Journal:  Br J Cancer       Date:  2005-11-28       Impact factor: 7.640
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  19 in total

1.  A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

Authors:  Athina-Myrto Chioni; William J Brackenbury; Jeffrey D Calhoun; Lori L Isom; Mustafa B A Djamgoz
Journal:  Int J Biochem Cell Biol       Date:  2008-11-12       Impact factor: 5.085

2.  Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer.

Authors:  Brook Chernet; Michael Levin
Journal:  J Clin Exp Oncol       Date:  2013

3.  Bioelectric Control of Metastasis in Solid Tumors.

Authors:  Samantha L Payne; Michael Levin; Madeleine J Oudin
Journal:  Bioelectricity       Date:  2019-09-16

4.  Alteration of bioelectrically-controlled processes in the embryo: a teratogenic mechanism for anticonvulsants.

Authors:  Sonia Hernández-Díaz; Michael Levin
Journal:  Reprod Toxicol       Date:  2014-05-06       Impact factor: 3.143

Review 5.  An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers.

Authors:  William J Brackenbury; Mustafa B A Djamgoz; Lori L Isom
Journal:  Neuroscientist       Date:  2008-10-20       Impact factor: 7.519

6.  Activation of cell migration with fibroblast growth factor-2 requires calcium-sensitive potassium channels.

Authors:  Wolfram Kessler; Thomas Budde; Michael Gekle; Anke Fabian; Albrecht Schwab
Journal:  Pflugers Arch       Date:  2008-01-29       Impact factor: 3.657

Review 7.  Dual roles of voltage-gated sodium channels in development and cancer.

Authors:  Faheemmuddeen Patel; William J Brackenbury
Journal:  Int J Dev Biol       Date:  2015       Impact factor: 2.203

Review 8.  Voltage-gated sodium channels and metastatic disease.

Authors:  William J Brackenbury
Journal:  Channels (Austin)       Date:  2012-09-01       Impact factor: 2.581

9.  Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway.

Authors:  Yan-Lin He; Dong-Dong Liu; Yan-Jia Fang; Xiao-Qin Zhan; Jin-Jing Yao; Yan-Ai Mei
Journal:  PLoS One       Date:  2013-01-22       Impact factor: 3.240

10.  Epidermal growth factor potentiates in vitro metastatic behaviour of human prostate cancer PC-3M cells: involvement of voltage-gated sodium channel.

Authors:  Pinar Uysal-Onganer; Mustafa Ba Djamgoz
Journal:  Mol Cancer       Date:  2007-11-24       Impact factor: 27.401
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