Literature DB >> 17960095

Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds.

Norbert Haider1, Tamara Kabicher, Johann Käferböck, Angelika Plenk.   

Abstract

A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.

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Year:  2007        PMID: 17960095      PMCID: PMC6149133          DOI: 10.3390/12081900

Source DB:  PubMed          Journal:  Molecules        ISSN: 1420-3049            Impact factor:   4.411


  4 in total

1.  1,5-dimethyl-6H-pyridazino[4,5-b]carbazole, a 3-aza bioisoster of the antitumor alkaloid olivacine.

Authors:  Norbert Haider; Eddy Sotelo
Journal:  Chem Pharm Bull (Tokyo)       Date:  2002-11       Impact factor: 1.645

2.  [On 1-nitroisoquinoline].

Authors:  E Hayashi; Y Akahori; Y Yamamoto
Journal:  Yakugaku Zasshi       Date:  1967-11       Impact factor: 0.302

3.  Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.

Authors:  Karem Shanab; Nipawan Pongprom; Eva Wulz; Wolfgang Holzer; Helmut Spreitzer; Peter Schmidt; Babette Aicher; Gilbert Müller; Eckhard Günther
Journal:  Bioorg Med Chem Lett       Date:  2007-09-18       Impact factor: 2.823

4.  Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

Authors:  D A Scudiero; R H Shoemaker; K D Paull; A Monks; S Tierney; T H Nofziger; M J Currens; D Seniff; M R Boyd
Journal:  Cancer Res       Date:  1988-09-01       Impact factor: 12.701

  4 in total
  1 in total

1.  Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors.

Authors:  Samir M El Rayes; Gaber El Enany; Ibrahim A I Ali; Wessam Ibrahim; Mohamed S Nafie
Journal:  ACS Omega       Date:  2022-06-27
  1 in total

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