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Literature DB >> 17956762

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

Abstract

SNARE proteins and the Sec1/Munc18 (SM) protein, Munc18-1, are essential components of the mammalian secretion machinery. Until recently, quite divergent working models existed for the central but rather isolated role of Munc18-1 in secretion and its relation to the SNAREs. New studies now solve old discrepancies, bring consensus among SM-SNARE interactions and emphasize how closely these proteins work together. Together, SM and SNARE proteins control each step in the exocytotic pathway as a team. Munc18-1 operates as the chief commander of the exocytotic SNARE team, making teamwork more efficient, working with specific team members on specific jobs, reducing promiscuity with members of noncognate teams, and adjusting team efforts as a function of recent history and environmental cues (presynaptic receptor activation).

Entities: Gene Species

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Year: 2007 PMID： 17956762 DOI： 10.1016/j.tins.2007.08.008

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

96 in total

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Review 2. Short-term presynaptic plasticity.

Authors: Wade G Regehr
Journal: Cold Spring Harb Perspect Biol Date: 2012-07-01 Impact factor: 10.005

3. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

Authors: Shu-Hong Hu; Michelle P Christie; Natalie J Saez; Catherine F Latham; Russell Jarrott; Linda H L Lua; Brett M Collins; Jennifer L Martin
Journal: Proc Natl Acad Sci U S A Date: 2010-12-30 Impact factor: 11.205

4. The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.

Authors: Wei Li; Cong Ma; Rong Guan; Yibin Xu; Diana R Tomchick; Josep Rizo
Journal: Structure Date: 2011-10-12 Impact factor: 5.006

5. Single-molecule measurements of dissociation rates and energy landscapes of binary trans snare complexes in parallel versus antiparallel orientation.

Authors: Wei Liu; Vedrana Montana; Vladimir Parpura; U Mohideen
Journal: Biophys J Date: 2011-10-19 Impact factor: 4.033

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

Review 1. Neurotransmitters and integration in neuronal-astroglial networks.

Review 2. Short-term presynaptic plasticity.

3. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

4. The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.

5. Single-molecule measurements of dissociation rates and energy landscapes of binary trans snare complexes in parallel versus antiparallel orientation.

6. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.

7. Unique mechanism of plant endocytic/vacuolar transport pathways.

Review 8. The Ca(2+)-dependent activator protein for secretion CAPS: do I dock or do I prime?

9. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission.

Review 10. Molecular machines governing exocytosis of synaptic vesicles.