Literature DB >> 17954702

Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.

Partha Palit1, Nahid Ali.   

Abstract

Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.

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Year:  2007        PMID： 17954702      PMCID： PMC2223878          DOI： 10.1128/AAC.00522-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

2.  Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes.

Authors:  J D Maya; A Morello; Y Repetto; R Tellez; A Rodriguez; U Zelada; P Puebla; E Caballero; M Medarde; L J Núñez-Vergara; J A Squella; M Bontá; S Bollo; A San Feliciano
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2000-01       Impact factor: 3.228

3.  Biochemistry of Pentostam resistant Leishmania.

Authors:  J D Berman; N Edwards; M King; M Grogl
Journal:  Am J Trop Med Hyg       Date:  1989-02       Impact factor: 2.345

4.  Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani.

Authors:  N Sen; B B Das; A Ganguly; T Mukherjee; G Tripathi; S Bandyopadhyay; S Rakshit; T Sen; H K Majumder
Journal:  Cell Death Differ       Date:  2004-08       Impact factor: 15.828

5.  Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.

Authors:  Juan Román Luque-Ortega; Luis Rivas
Journal:  Antimicrob Agents Chemother       Date:  2007-02-05       Impact factor: 5.191

6.  Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity.

Authors:  Ashish Mehta; Chandrima Shaha
Journal:  J Biol Chem       Date:  2003-12-16       Impact factor: 5.157

7.  Inhibition of cancer cell growth by calcium channel antagonists in the athymic mouse.

Authors:  J M Taylor; R U Simpson
Journal:  Cancer Res       Date:  1992-05-01       Impact factor: 12.701

8.  Involvement of the nitric oxide system in the anti-atherosclerotic potential of lacidipine in the ApoE-deficient mouse: a morphological, functional, and electrochemical study.

Authors:  Patrizia G Cristofori; Federica A Crivellente; Ivo Faustinelli; Anna R Lanzoni; Chiara Lazzarini; Elena Vecchiato; Michela Andreoli; John A Turton; Carlo Zancanaro; Francesco M Crespi
Journal:  Toxicol Pathol       Date:  2004 Jul-Aug       Impact factor: 1.902

9.  Role of Ca2+ ion on Leishmania-macrophage attachment.

Authors:  S Misra; K Naskar; D Sarkar; D K Ghosh
Journal:  Mol Cell Biochem       Date:  1991-03-27       Impact factor: 3.396

10.  Amlodipine: a cardiovascular drug with powerful antimicrobial property.

Authors:  K Asok Kumar; Kumkum Ganguly; Kaushiki Mazumdar; N K Dutta; Sujata G Dastidar; A N Chakrabarty
Journal:  Acta Microbiol Pol       Date:  2003
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  8 in total

1.  Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.

Authors:  Yara Almeida Machado; Maria Terezinha Bahia; Ivo Santana Caldas; Ana Lia Mazzeti; Rômulo Dias Novaes; Breno Raimundo Vilas Boas; Lorena Júnia de Souza Santos; Olindo Assis Martins-Filho; Marcos José Marques; Lívia de Figueiredo Diniz
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191

2.  1,4-Dihydropyridine as a Promising Scaffold for Novel Antimicrobials Against Helicobacter pylori.

Authors:  Andrés González; Javier Casado; Miyase Gözde Gündüz; Brisa Santos; Adrián Velázquez-Campoy; Cristina Sarasa-Buisan; María F Fillat; Milagrosa Montes; Elena Piazuelo; Ángel Lanas
Journal:  Front Microbiol       Date:  2022-05-25       Impact factor: 6.064

3.  Antileishmanial activity and ultrastructural alterations of Leishmania (L.) chagasi treated with the calcium channel blocker nimodipine.

Authors:  André Gustavo Tempone; Noemi Nosomi Taniwaki; Juliana Quero Reimão
Journal:  Parasitol Res       Date:  2009-04-08       Impact factor: 2.289

4.  Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection.

Authors:  Shaobo Wang; Yang Liu; Jiao Guo; Peilin Wang; Leike Zhang; Gengfu Xiao; Wei Wang
Journal:  J Virol       Date:  2017-10-13       Impact factor: 5.103

5.  Repurposing Dihydropyridines for Treatment of Helicobacter pylori Infection.

Authors:  Andrés González; Javier Casado; Eduardo Chueca; Sandra Salillas; Adrián Velázquez-Campoy; Vladimir Espinosa Angarica; Lucie Bénejat; Jérome Guignard; Alban Giese; Javier Sancho; Philippe Lehours; Ángel Lanas
Journal:  Pharmaceutics       Date:  2019-12-15       Impact factor: 6.321

6.  Antileishmanial activity of the estrogen receptor modulator raloxifene.

Authors:  Juliana Q Reimão; Danilo C Miguel; Noemi N Taniwaki; Cristiana T Trinconi; Jenicer K U Yokoyama-Yasunaka; Silvia R B Uliana
Journal:  PLoS Negl Trop Dis       Date:  2014-05-08

7.  Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum.

Authors:  Juliana Quero Reimão; Juliana Tonini Mesquita; Daiane Dias Ferreira; Andre Gustavo Tempone
Journal:  Evid Based Complement Alternat Med       Date:  2016-01-28       Impact factor: 2.629

Review 8.  Targeting Channels and Transporters in Protozoan Parasite Infections.

Authors:  Anna Meier; Holger Erler; Eric Beitz
Journal:  Front Chem       Date:  2018-03-27       Impact factor: 5.221
  8 in total

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