OBJECTIVES: The objectives of the study were to evaluate the clinical significance of lifetime eating disorder comorbidity in a well-defined sample of patients with bipolar spectrum disorders and to describe cognitive correlates of disordered eating in this group. METHOD: Twenty-six bipolar patients with a lifetime history of a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-defined eating disorder (n = 17) or a clinically significant subthreshold eating disorder (n = 9) (ED group) were compared with 46 bipolar patients with no history of an eating disorder (no-ED group) on demographic and clinical characteristics at study presentation, history of bipolar illness, and other psychiatric comorbidity. Measures included the Structured Clinical Interview for the DSM-IV Axis I Disorders, the Clinical Global Impression-Severity Scale-Bipolar Version (CGI-S-BP), and the Eating Disorder Examination. Height and weight were recorded to calculate body mass index. RESULTS: Patients in the ED group were heavier and were rated as more symptomatic on the CGI-S-BP than were patients in the no-ED group. The ED group also had a higher number of lifetime depressive episodes and greater psychiatric comorbidity, excluding eating and mood disorders. Finally, after controlling for body mass index and CGI-S-BP rating, patients in the ED group had significantly higher Eating Disorder Examination Restraint, Eating Concern, Shape Concern, Weight Concern, and Global scores than did patients in the no-ED group. CONCLUSIONS: These findings highlight the need for a renewed emphasis on the evaluation and management of weight and eating in the mood disorders. In particular, this research suggests that eating disorder comorbidity may be a marker for increased symptom load and illness burden in bipolar disorder.
OBJECTIVES: The objectives of the study were to evaluate the clinical significance of lifetime eating disorder comorbidity in a well-defined sample of patients with bipolar spectrum disorders and to describe cognitive correlates of disordered eating in this group. METHOD: Twenty-six bipolarpatients with a lifetime history of a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-defined eating disorder (n = 17) or a clinically significant subthreshold eating disorder (n = 9) (ED group) were compared with 46 bipolarpatients with no history of an eating disorder (no-ED group) on demographic and clinical characteristics at study presentation, history of bipolar illness, and other psychiatric comorbidity. Measures included the Structured Clinical Interview for the DSM-IV Axis I Disorders, the Clinical Global Impression-Severity Scale-Bipolar Version (CGI-S-BP), and the Eating Disorder Examination. Height and weight were recorded to calculate body mass index. RESULTS:Patients in the ED group were heavier and were rated as more symptomatic on the CGI-S-BP than were patients in the no-ED group. The ED group also had a higher number of lifetime depressive episodes and greater psychiatric comorbidity, excluding eating and mood disorders. Finally, after controlling for body mass index and CGI-S-BP rating, patients in the ED group had significantly higher Eating Disorder Examination Restraint, Eating Concern, Shape Concern, Weight Concern, and Global scores than did patients in the no-ED group. CONCLUSIONS: These findings highlight the need for a renewed emphasis on the evaluation and management of weight and eating in the mood disorders. In particular, this research suggests that eating disorder comorbidity may be a marker for increased symptom load and illness burden in bipolar disorder.
Authors: Susan L McElroy; Mark A Frye; Trisha Suppes; Dawn Dhavale; Paul E Keck; Gabriele S Leverich; Lori Altshuler; Kirk D Denicoff; Willem A Nolen; Ralph Kupka; Heinz Grunze; Jorg Walden; Robert M Post Journal: J Clin Psychiatry Date: 2002-03 Impact factor: 4.384
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Authors: Robert M Post; Gabriele S Leverich; Lori L Altshuler; Mark A Frye; Trisha M Suppes; Paul E Keck; Susan L McElroy; Ralph Kupka; Willem A Nolen; Heinz Grunze; Jorg Walden Journal: Bipolar Disord Date: 2003-10 Impact factor: 6.744
Authors: Glenda M MacQueen; Michael Marriott; Helen Begin; Janine Robb; Russell T Joffe; L Trevor Young Journal: Bipolar Disord Date: 2003-10 Impact factor: 6.744
Authors: Andrea Fagiolini; David J Kupfer; Patricia R Houck; Danielle M Novick; Ellen Frank Journal: Am J Psychiatry Date: 2003-01 Impact factor: 18.112
Authors: Stacey J Winham; Alfredo B Cuellar-Barboza; Susan L McElroy; Alfredo Oliveros; Scott Crow; Colin L Colby; Doo-Sup Choi; Mohit Chauhan; Mark A Frye; Joanna M Biernacka Journal: J Affect Disord Date: 2014-04-19 Impact factor: 4.839
Authors: Danielle R Balzafiore; Natalie L Rasgon; Laura D Yuen; Saloni Shah; Hyun Kim; Kathryn C Goffin; Shefali Miller; Po W Wang; Terence A Ketter Journal: Int J Bipolar Disord Date: 2017-08-12