RATIONALE: The inbred Roman high- (RHA-I) and low-avoidance (RLA-I) rats, differing in dopaminergic activity and novelty/substance-seeking profiles, may be a suitable model to study the implication of the dopaminergic system in vulnerability to drug abuse. Differences in D3 receptor binding recently described between the two strains (Guitart-Masip M, Johansson B, Fernández-Teruel A, Cañete T, Tobeña A, Terenius L, Giménez-Llort L, Neuroscience 142:1231-1243, 2006b) may be important in shaping the aforementioned differences in novelty seeking. OBJECTIVE: The aim of the present work was to study the effect of D3 receptor activation on novelty-induced locomotor activity in these two strains of rats. MATERIALS AND METHODS: We administered saline and PD-128,907 (0.01 and 0.1 mg/kg), a putative D3 receptor agonist, to the Roman rats and studied the locomotor activity when animals were placed in a novel environment. Thereafter, by means of in situ hybridization, nerve growth factor inducible clone A (NGFI-A) mRNA was measured in the striatum and the Calleja islands of these animals. RESULTS: We found that RLA-I rats showed stronger locomotor inhibition than RHA-I rats after PD-128,907 administration. Moreover, RLA-I rats showed stronger reduction of NGFI-A mRNA in the Calleja islands than RHA-I rats. CONCLUSIONS: These results, together with previous findings, suggest that differences in D3 receptor expression in the Calleja islands may contribute to the divergent behavioral effect of PD-128,907 administration in the two strains of Roman rats.
RATIONALE: The inbred Roman high- (RHA-I) and low-avoidance (RLA-I) rats, differing in dopaminergic activity and novelty/substance-seeking profiles, may be a suitable model to study the implication of the dopaminergic system in vulnerability to drug abuse. Differences in D3 receptor binding recently described between the two strains (Guitart-Masip M, Johansson B, Fernández-Teruel A, Cañete T, Tobeña A, Terenius L, Giménez-Llort L, Neuroscience 142:1231-1243, 2006b) may be important in shaping the aforementioned differences in novelty seeking. OBJECTIVE: The aim of the present work was to study the effect of D3 receptor activation on novelty-induced locomotor activity in these two strains of rats. MATERIALS AND METHODS: We administered saline and PD-128,907 (0.01 and 0.1 mg/kg), a putative D3 receptor agonist, to the Roman rats and studied the locomotor activity when animals were placed in a novel environment. Thereafter, by means of in situ hybridization, nerve growth factor inducible clone A (NGFI-A) mRNA was measured in the striatum and the Calleja islands of these animals. RESULTS: We found that RLA-I rats showed stronger locomotor inhibition than RHA-I rats after PD-128,907 administration. Moreover, RLA-I rats showed stronger reduction of NGFI-A mRNA in the Calleja islands than RHA-I rats. CONCLUSIONS: These results, together with previous findings, suggest that differences in D3 receptor expression in the Calleja islands may contribute to the divergent behavioral effect of PD-128,907 administration in the two strains of Roman rats.
Authors: M Xu; T E Koeltzow; G T Santiago; R Moratalla; D C Cooper; X T Hu; N M White; A M Graybiel; F J White; S Tonegawa Journal: Neuron Date: 1997-10 Impact factor: 17.173
Authors: M Guitart-Masip; B Johansson; A Fernández-Teruel; T Cañete; A Tobeña; L Terenius; L Giménez-Llort Journal: Neuroscience Date: 2006-09-26 Impact factor: 3.590
Authors: Laurel M Pritchard; Aaron D Logue; Scott Hayes; Jeffrey A Welge; Ming Xu; Jianhua Zhang; S Paul Berger; Neil M Richtand Journal: Neuropsychopharmacology Date: 2003-01 Impact factor: 7.853
Authors: T A Pugsley; M D Davis; H C Akunne; R G MacKenzie; Y H Shih; G Damsma; H Wikstrom; S Z Whetzel; L M Georgic; L W Cooke Journal: J Pharmacol Exp Ther Date: 1995-12 Impact factor: 4.030
Authors: Ignasi Oliveras; Ana Sánchez-González; Daniel Sampedro-Viana; Maria Antonietta Piludu; Cristóbal Río-Alamos; Osvaldo Giorgi; Maria G Corda; Susana Aznar; Javier González-Maeso; Cristina Gerbolés; Gloria Blázquez; Toni Cañete; Adolf Tobeña; Alberto Fernández-Teruel Journal: Psychopharmacology (Berl) Date: 2017-02-02 Impact factor: 4.530
Authors: Margarita Moreno; Diana Cardona; Maria José Gómez; Fernando Sánchez-Santed; Adolf Tobeña; Alberto Fernández-Teruel; Leticia Campa; Cristina Suñol; Maria Dolores Escarabajal; Carmen Torres; Pilar Flores Journal: Neuropsychopharmacology Date: 2010-01-20 Impact factor: 7.853