Literature DB >> 17951665

Bone histomorphometry in arthritis models.

Georg Schett, Birgit Tuerk.   

Abstract

Rodent arthritis models are tools to study joint destruction. This chapter describes methods to prepare and analyze histological sections from inflamed paws. Protocols to create decalcified paraffin-embedded as well as undecalcified plastic-embedded sections are provided. Strengths and limitations of these two histological techniques are described. Major staining techniques on hard tissue sections focusing on the evaluation of joint destruction are indicated. Finally, evaluation of arthritic paw sections by histomorphometry, a semiautomated computerized method to measure areas of interest, is described.

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Year:  2007        PMID： 17951665     DOI： 10.1007/978-1-59745-401-8_17

Source DB:  PubMed          Journal:  Methods Mol Med        ISSN： 1543-1894


  5 in total

1.  JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis.

Authors:  Katja Denninger; Susanne Rasmussen; Jeppe Madura Larsen; Catrine Orskov; Steen Seier Poulsen; Poul Sørensen; Jan Pravsgaard Christensen; Harald Illges; Niels Odum; Tord Labuda
Journal:  Am J Pathol       Date:  2011-08-11       Impact factor: 4.307

2.  Juvenile dermatomyositis calcifications selectively displayed markers of bone formation.

Authors:  Annette L Urganus; Yong-Dong Zhao; Lauren M Pachman
Journal:  Arthritis Rheum       Date:  2009-04-15

3.  Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease.

Authors:  Eva N Hadaschik; Xiaoying Wei; Harald Leiss; Britta Heckmann; Birgit Niederreiter; Günter Steiner; Walter Ulrich; Alexander H Enk; Josef S Smolen; Georg H Stummvoll
Journal:  Arthritis Res Ther       Date:  2015-02-23       Impact factor: 5.156

4.  Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis.

Authors:  Julie Teresa Marchesan; Elizabeth Ann Gerow; Riley Schaff; Andrei Dan Taut; Seung-Yun Shin; James Sugai; David Brand; Aaron Burberry; Julie Jorns; Steven Karl Lundy; Gabriel Nuñez; David A Fox; William V Giannobile
Journal:  Arthritis Res Ther       Date:  2013-11-12       Impact factor: 5.156

5.  MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus.

Authors:  Harald Leiss; Wilhelm Salzberger; Barbara Jacobs; Irina Gessl; Nicolas Kozakowski; Stephan Blüml; Antonia Puchner; Attila Kiss; Bruno K Podesser; Josef S Smolen; Georg H Stummvoll
Journal:  PLoS One       Date:  2017-07-18       Impact factor: 3.240
  5 in total

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