Literature DB >> 17951664

Analysis of TIMP expression and activity.

Linda Troeberg, Hideaki Nagase.   

Abstract

This chapter provides practical information on the assay of tissue inhibitor of metalloproteinase (TIMP) activity and background information enabling meaningful interpretation of the data. Protocols are given for assessing the presence of TIMPs in biological samples by immunoblotting and by virtue of their ability to inhibit matrix metalloproteinase (MMP) hydrolysis of protein substrates (reverse zymography) and synthetic fluorogenic substrates.

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Year:  2007        PMID： 17951664     DOI： 10.1007/978-1-59745-401-8_16

Source DB:  PubMed          Journal:  Methods Mol Med        ISSN： 1543-1894


  8 in total

1.  The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well.

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Journal:  Br J Pharmacol       Date:  2009-09-28       Impact factor: 8.739

2.  Effect of elastin-derived peptides on the production of tissue inhibitor of metalloproteinase-1, -2, and -3 and the ratios in various endothelial cell lines.

Authors:  Krzysztof Siemianowicz; Wirginia Likus; Tomasz Francuz; Wojciech Garczorz
Journal:  Exp Ther Med       Date:  2015-04-17       Impact factor: 2.447

Review 3.  Is there new hope for therapeutic matrix metalloproteinase inhibition?

Authors:  Roosmarijn E Vandenbroucke; Claude Libert
Journal:  Nat Rev Drug Discov       Date:  2014-11-07       Impact factor: 84.694

4.  Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.

Authors:  Ki Baek Lee; Dong Hyun Nam; Jacob A M Nuhn; Juan Wang; Ian C Schneider; Xin Ge
Journal:  Microb Cell Fact       Date:  2017-04-28       Impact factor: 5.328

Review 5.  Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.

Authors:  Qichan Hu; Melanie Ecker
Journal:  Int J Mol Sci       Date:  2021-02-09       Impact factor: 5.923

Review 6.  The "Elastic Perspective" of SARS-CoV-2 Infection and the Role of Intrinsic and Extrinsic Factors.

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Journal:  Int J Mol Sci       Date:  2022-01-29       Impact factor: 5.923

7.  Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage Ex Vivo and in a Rat Osteoarthritis Model.

Authors:  Mirella J J Haartmans; Ufuk Tan Timur; Kaj S Emanuel; Marjolein M J Caron; Ralph M Jeuken; Tim J M Welting; Gerjo J V M van Osch; Ron M A Heeren; Berta Cillero-Pastor; Pieter J Emans
Journal:  Cartilage       Date:  2022 Jul-Sep       Impact factor: 3.117

8.  Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP.

Authors:  Naja Becher; Merete Hein; Niels Uldbjerg; Carl Christian Danielsen
Journal:  Reprod Biol Endocrinol       Date:  2008-09-30       Impact factor: 5.211
  8 in total

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