Literature DB >> 17951386

Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket.

Karl A Hassan1, Ronald A Skurray, Melissa H Brown.   

Abstract

An acidic residue in transmembrane segment (TMS) 10 is important for recognition of bivalent cationic substrates by the QacA multidrug transporter. Remarkably, an acidic residue in TMS 12 compensated for the absence of such a residue in TMS 10, suggesting that TMS 12 is a component of the bivalent cation-binding region.

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Year:  2007        PMID： 17951386      PMCID： PMC2168635          DOI： 10.1128/JB.01492-07

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  Structural mechanisms of QacR induction and multidrug recognition.

Authors:  M A Schumacher; M C Miller; S Grkovic; M H Brown; R A Skurray; R G Brennan
Journal:  Science       Date:  2001-12-07       Impact factor: 47.728

2.  Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA.

Authors:  Zhiqiang Xu; Brendon A O'Rourke; Ronald A Skurray; Melissa H Brown
Journal:  J Biol Chem       Date:  2005-11-09       Impact factor: 5.157

Review 3.  Staphylococcal multidrug efflux protein QacA.

Authors:  M H Brown; R A Skurray
Journal:  J Mol Microbiol Biotechnol       Date:  2001-04

4.  Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.

Authors:  I T Paulsen; M H Brown; T G Littlejohn; B A Mitchell; R A Skurray
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

5.  Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic compounds.

Authors:  Piotr Mazurkiewicz; Wil N Konings; Gerrit J Poelarends
Journal:  J Biol Chem       Date:  2002-05-06       Impact factor: 5.157

6.  Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates.

Authors:  Julia Adler; Eitan Bibi
Journal:  J Biol Chem       Date:  2004-11-22       Impact factor: 5.157

7.  A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

Authors:  R Edgar; E Bibi
Journal:  EMBO J       Date:  1999-02-15       Impact factor: 11.598

8.  Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA.

Authors:  Julia Adler; Oded Lewinson; Eitan Bibi
Journal:  Biochemistry       Date:  2004-01-20       Impact factor: 3.162

9.  Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.

Authors:  B A Mitchell; I T Paulsen; M H Brown; R A Skurray
Journal:  J Biol Chem       Date:  1999-02-05       Impact factor: 5.157

10.  Analysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus.

Authors:  Mohammed Mahbub Alam; Nobumichi Kobayashi; Nobuyuki Uehara; Naoki Watanabe
Journal:  Microb Drug Resist       Date:  2003       Impact factor: 3.431
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  7 in total

1.  Physical enrichment of transposon mutants from saturation mutant libraries using the TraDISort approach.

Authors:  Ian T Paulsen; Amy K Cain; Karl A Hassan
Journal:  Mob Genet Elements       Date:  2017-03-31

2.  A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis.

Authors:  Xuan Qin; Danielle M Zerr; Amin Addetia; Alexander L Greninger; Amanda Adler; Shuhua Yuan; Negar Makhsous
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

Review 3.  Review and phylogenetic analysis of qac genes that reduce susceptibility to quaternary ammonium compounds in Staphylococcus species.

Authors:  Trudy M Wassenaar; David Ussery; Lene N Nielsen; Hanne Ingmer
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2015-03-26

4.  Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus.

Authors:  Hidemasa Nakaminami; Norihisa Noguchi; Masanori Sasatsu
Journal:  Antimicrob Agents Chemother       Date:  2010-07-26       Impact factor: 5.191

5.  Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane.

Authors:  Karl A Hassan; Talal Souhani; Ronald A Skurray; Melissa H Brown
Journal:  J Bacteriol       Date:  2008-01-25       Impact factor: 3.490

Review 6.  Biochemistry of bacterial multidrug efflux pumps.

Authors:  Sanath Kumar; Manuel F Varela
Journal:  Int J Mol Sci       Date:  2012-04-10       Impact factor: 6.208

7.  Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA.

Authors:  Jingqin Wu; Karl A Hassan; Ronald A Skurray; Melissa H Brown
Journal:  BMC Microbiol       Date:  2008-09-16       Impact factor: 3.605
  7 in total

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