Literature DB >> 17951294

Passage times for polymer translocation pulled through a narrow pore.

Debabrata Panja1, Gerard T Barkema.   

Abstract

We study the passage times of a translocating polymer of length N in three dimensions, while it is pulled through a narrow pore with a constant force F applied to one end of the polymer. At small to moderate forces, satisfying the condition FN(nu)/k(B)T less, similar 1, where nu approximately 0.588 is the Flory exponent for the polymer, we find that tau(N), the mean time the polymer takes to leave the pore, scales as N(2+nu) independent of F, in agreement with our earlier result for F = 0. At strong forces, i.e., for, FN(nu)/k(B)T >> 1, the behavior of the passage time crosses over to tau(N) approximately N(2)/F. We show here that these behaviors stem from the polymer dynamics at the immediate vicinity of the pore-in particular, the memory effects in the polymer chain tension imbalance across the pore.

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Year:  2007        PMID: 17951294      PMCID: PMC2242752          DOI: 10.1529/biophysj.107.116434

Source DB:  PubMed          Journal:  Biophys J        ISSN: 0006-3495            Impact factor:   4.033


  36 in total

1.  Coil-to-stretch transition, kink formation, and efficient barrier crossing of a flexible chain.

Authors:  S Lee; W Sung
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2001-01-26

2.  Polymer Translocation through a Pore in a Membrane.

Authors: 
Journal:  Phys Rev Lett       Date:  1996-07-22       Impact factor: 9.161

3.  Sequence-specific detection of individual DNA strands using engineered nanopores.

Authors:  S Howorka; S Cheley; H Bayley
Journal:  Nat Biotechnol       Date:  2001-07       Impact factor: 54.908

4.  Driven DNA transport into an asymmetric nanometer-scale pore.

Authors:  S E Henrickson; M Misakian; B Robertson; J J Kasianowicz
Journal:  Phys Rev Lett       Date:  2000-10-02       Impact factor: 9.161

5.  Rapid nanopore discrimination between single polynucleotide molecules.

Authors:  A Meller; L Nivon; E Brandin; J Golovchenko; D Branton
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

6.  Dynamics of molecular motors and polymer translocation with sequence heterogeneity.

Authors:  Yariv Kafri; David K Lubensky; David R Nelson
Journal:  Biophys J       Date:  2004-06       Impact factor: 4.033

7.  Nanopore unzipping of individual DNA hairpin molecules.

Authors:  Jérôme Mathé; Hasina Visram; Virgile Viasnoff; Yitzhak Rabin; Amit Meller
Journal:  Biophys J       Date:  2004-09-03       Impact factor: 4.033

8.  Characterization of individual polynucleotide molecules using a membrane channel.

Authors:  J J Kasianowicz; E Brandin; D Branton; D W Deamer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

9.  Identification and characterization of a cell membrane nucleic acid channel.

Authors:  B Hanss; E Leal-Pinto; L A Bruggeman; T D Copeland; P E Klotman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

Review 10.  Supervising the fold: functional principles of molecular chaperones.

Authors:  J Buchner
Journal:  FASEB J       Date:  1996-01       Impact factor: 5.191

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