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Literature DB >> 17951163

Regulatory role of cathepsin D in apoptosis.

Alina Minarowska¹, Lukasz Minarowski, Alicja Karwowska, Marek Gacko.

Abstract

Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.

Entities: Gene

Mesh：

Substances：
Cathepsin D

Year: 2007 PMID： 17951163

Source DB: PubMed Journal: Folia Histochem Cytobiol ISSN： 0239-8508 Impact factor: 1.698

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Regulatory role of cathepsin D in apoptosis.

1. Kaposi's Sarcoma-associated Herpesvirus microRNA mutants modulate cancer hallmark phenotypic differences in human endothelial cells.

2. The function of cathepsins B, D, and X in atherosclerosis.

3. Endocytotic routes of cobra cardiotoxins depend on spatial distribution of positively charged and hydrophobic domains to target distinct types of sulfated glycoconjugates on cell surface.

4. Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells.

5. Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.

6. ISSLS PRIZE IN CLINICAL SCIENCE 2017: Is infection the possible initiator of disc disease? An insight from proteomic analysis.

7. VPS52 induces apoptosis via cathepsin D in gastric cancer.

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9. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection.

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