Literature DB >> 17950636

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.

Zlatka Kostova1, Yien Che Tsai, Allan M Weissman.   

Abstract

Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action.

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Year:  2007        PMID： 17950636      PMCID： PMC2200800          DOI： 10.1016/j.semcdb.2007.09.002

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  91 in total

1.  Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin.

Authors:  Yuxian Shen; Petek Ballar; Shengyun Fang
Journal:  Biochem Biophys Res Commun       Date:  2006-09-07       Impact factor: 3.575

2.  Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

Authors:  Christian Schuberth; Alexander Buchberger
Journal:  Nat Cell Biol       Date:  2005-09-18       Impact factor: 28.824

3.  Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.

Authors:  Satoshi Yamasaki; Naoko Yagishita; Takeshi Sasaki; Minako Nakazawa; Yukihiro Kato; Tadayuki Yamadera; Eunkyung Bae; Sayumi Toriyama; Rie Ikeda; Lei Zhang; Kazuko Fujitani; Eunkyung Yoo; Kaneyuki Tsuchimochi; Tomohiko Ohta; Natsumi Araya; Hidetoshi Fujita; Satoko Aratani; Katsumi Eguchi; Setsuro Komiya; Ikuro Maruyama; Nobuyo Higashi; Mitsuru Sato; Haruki Senoo; Takahiro Ochi; Shigeyuki Yokoyama; Tetsuya Amano; Jaeseob Kim; Steffen Gay; Akiyoshi Fukamizu; Kusuki Nishioka; Keiji Tanaka; Toshihiro Nakajima
Journal:  EMBO J       Date:  2006-12-14       Impact factor: 11.598

4.  Structural insights into the p97-Ufd1-Npl4 complex.

Authors:  Valerie E Pye; Fabienne Beuron; Catherine A Keetch; Ciaran McKeown; Carol V Robinson; Hemmo H Meyer; Xiaodong Zhang; Paul S Freemont
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-03       Impact factor: 11.205

5.  Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.

Authors:  Joon No Lee; Baoliang Song; Russell A DeBose-Boyd; Jin Ye
Journal:  J Biol Chem       Date:  2006-10-16       Impact factor: 5.157

6.  Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase.

Authors:  Min Deng; Mark Hochstrasser
Journal:  Nature       Date:  2006-10-19       Impact factor: 49.962

7.  Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.

Authors:  Jing Liang; Chaobo Yin; Howard Doong; Shengyun Fang; Corrine Peterhoff; Ralph A Nixon; Mervyn J Monteiro
Journal:  J Cell Sci       Date:  2006-09-12       Impact factor: 5.285

8.  Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

Authors:  Bao-Liang Song; Navdar Sever; Russell A DeBose-Boyd
Journal:  Mol Cell       Date:  2005-09-16       Impact factor: 17.970

9.  A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.

Authors:  H H Meyer; J G Shorter; J Seemann; D Pappin; G Warren
Journal:  EMBO J       Date:  2000-05-15       Impact factor: 11.598

10.  Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.

Authors:  R K Plemper; J Bordallo; P M Deak; C Taxis; R Hitt; D H Wolf
Journal:  J Cell Sci       Date:  1999-11       Impact factor: 5.285
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  88 in total

1.  Selective targeting of proteins within secretory pathway for endoplasmic reticulum-associated degradation.

Authors:  Lara Vecchi; Gianluca Petris; Marco Bestagno; Oscar R Burrone
Journal:  J Biol Chem       Date:  2012-04-20       Impact factor: 5.157

Review 2.  Ubiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteins.

Authors:  Damian D Guerra; Judy Callis
Journal:  Plant Physiol       Date:  2012-06-22       Impact factor: 8.340

3.  Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.

Authors:  Poulomi Acharya; Mingxiang Liao; Juan C Engel; Maria Almira Correia
Journal:  J Biol Chem       Date:  2010-11-24       Impact factor: 5.157

4.  Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis.

Authors:  Wei Su; Yidan Liu; Yang Xia; Zhi Hong; Jianming Li
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

5.  An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

Authors:  Margaret M P Pearce; Duncan B Wormer; Stephan Wilkens; Richard J H Wojcikiewicz
Journal:  J Biol Chem       Date:  2009-02-24       Impact factor: 5.157

6.  A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.

Authors:  Zlatka Kostova; Jennifer Mariano; Simone Scholz; Carolin Koenig; Allan M Weissman
Journal:  J Cell Sci       Date:  2009-04-14       Impact factor: 5.285

7.  Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation.

Authors:  Kathleen Corcoran; Xiaoli Wang; Lonnie Lybarger
Journal:  J Biol Chem       Date:  2009-04-14       Impact factor: 5.157

8.  Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD).

Authors:  Xiaoli Wang; Y Y Lawrence Yu; Nancy Myers; Ted H Hansen
Journal:  J Biol Chem       Date:  2013-06-25       Impact factor: 5.157

9.  Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2.

Authors:  Tingting Ju; William Bocik; Ananya Majumdar; Joel R Tolman
Journal:  Proteins       Date:  2010-04

10.  Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner.

Authors:  Kristina Oresic; Britta Mueller; Domenico Tortorella
Journal:  Biosci Rep       Date:  2009-06       Impact factor: 3.840
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