Literature DB >> 17950502

Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae.

Julie A Preston1, Ama-Tawiah Essilfie, Jay C Horvat, Margaret A Wade, Kenneth W Beagley, Peter G Gibson, Paul S Foster, Philip M Hansbro.   

Abstract

Asthma is a common inflammatory disease of the airways. Current therapies alleviate symptoms but do not treat the disease. We aim to develop effective immunomodulatory therapies (IMTs) for asthma that target the underlying causes of disease based on Streptococcus pneumoniae (Spn). The effect of Spn IMT on the development of asthma [allergic airways disease (AAD)] was determined in mice. Killed Spn was administered before, during or after ovalbumin sensitization, and the subsequent development of AAD was assessed. IMT attenuated T cell cytokine production, goblet cell hyperplasia, airways hyperresponsiveness (AHR), and eosinophil numbers in the blood, bronchoalveolar lavage fluid and peribronchial tissue. This indicates the potential of Spn as an IMT for asthma.

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Year:  2007        PMID： 17950502     DOI： 10.1016/j.vaccine.2007.09.034

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  27 in total

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Authors:  Alan C-Y Hsu; Kamal Dua; Malcolm R Starkey; Tatt-Jhong Haw; Prema M Nair; Kristy Nichol; Nathan Zammit; Shane T Grey; Katherine J Baines; Paul S Foster; Philip M Hansbro; Peter A Wark
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Review 3.  Harnessing regulatory T cells to suppress asthma: from potential to therapy.

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Review 4.  The Human Microbiota and Asthma.

Authors:  Aaron Ver Heul; Joseph Planer; Andrew L Kau
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5.  Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

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6.  A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.

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Authors:  Pavel Dutow; Sandra Lingner; Robert Laudeley; Silke Glage; Heinz-Gerd Hoymann; Anna-Maria Dittrich; Beate Fehlhaber; Meike Müller; Armin Braun; Andreas Klos
Journal:  Infect Immun       Date:  2013-07-01       Impact factor: 3.441

10.  Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice.

Authors:  Malcolm R Starkey; Richard Y Kim; Emma L Beckett; Heidi C Schilter; Doris Shim; Ama-Tawiah Essilfie; Duc H Nguyen; Kenneth W Beagley; Joerg Mattes; Charles R Mackay; Jay C Horvat; Philip M Hansbro
Journal:  PLoS One       Date:  2012-08-01       Impact factor: 3.240
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